Lancet Regional Health:通过筛查检出的结直肠癌患者的生存率

2022-07-10 MedSci原创 MedSci原创

通过筛查检出的结直肠癌患者的预后都非常好

得益于有组织的基于人群的筛查计划的可用性,现越来越多的早期结直肠癌 (CRC) 被及时发现。本文旨在分析欧洲国家通过筛查发现的 CRC 患者的生存概率。

研究人员从 9 个欧洲国家的 16 个基于人群的癌症登记处收集了 CRC 患者数据。纳入了从 CRC 筛查计划引入那一年到最近一年诊断出的、并可提供可用数据的癌症患者,并随访至2016年-2020年。


纳入患者的基础特征

共筛查了228134位患者的数据,其中134597位(确诊时的年龄 60-69岁)被纳入分析。22.3%(38080/134597)的患者是通过筛查检出的 CRC。大部分通过筛查检出的 CRC 都是 I-II 期(65.6%)的,而大部分不是通过筛查检出的 CRC 多是 III-IV 期(56.4%)的。通过筛查检出的 CRC 的5年总生存率和 CRC 特异性生存率分别是83.4%和89.2%;而不是通过筛查检出的 CRC 患者的总生存率和 CRC 特异性生存率均低的多,分别是57.5%和65.7%。


不同地区筛检出的病例的生存率

筛查检出癌症的有利生存期在每个分期都有观察到,筛查检出的 I、II、III 和 IV期 CRC 患者的5年总生存率分别是92.4%、87.9%、80.7%和32.3%。这种有利现象在每个国家的人群中都有观察到。

总之,通过筛查检出的癌症患者的预后都非常好。即使是通过筛查检出的少有晚期病例,无论检测方法如何,患者的生存率也远高于通常报告的生存率。虽然这些结果不能用于量化筛查效果,但它们为筛查检测到的 CRC 患者及其医生提供了有用且令人鼓舞的信息。

原始出处:

Rafael Cardoso, et al. Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: A population-based study in 9 countries. The Lancet Regional Health. July, 2022. https://doi.org/10.1016/j.lanepe.2022.100458

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    2022-09-30 howi
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    2022-11-10 shizhenshan
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    2022-07-10 younei

    lancet上果然牛,感谢梅斯更新及时

    0

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