FDA发出警告:怀孕20周以后避免使用非甾体类抗炎药(NSAIDs),可导致婴儿肾脏疾病和羊水减少

2020-10-16 MedSci原创 MedSci原创

未出生婴儿的羊水主要是由肾脏产生的,因此肾脏问题可能导致羊水含量降低,并引起并发症。

美国食品和药物管理局(FDA)发出警告,在怀孕20周以后使用非甾体类抗炎药(NSAIDs)可能会导致未出生婴儿患上罕见且严重的肾脏问题。怀孕约20周时,未出生婴儿的羊水主要是由肾脏产生的,因此肾脏问题可能导致羊水含量降低,并引起并发症。羊水为婴儿提供保护垫,帮助未出生的婴儿的肺、消化系统和肌肉发育。

NSAID Risks | Natural Solutions for Pain and Inflammation

图片来源:https://thenutritionalhealingcenter.com/nsaids-risks-natural-solutions/

数十年来,NSAIDs已被广泛用于治疗多种不同的长期和短期疾病(如关节炎,月经来潮,头痛,感冒和流感)引起的疼痛和发烧。NSAIDs通过阻止体内诱导炎症的化学物质的产生而起作用,包括阿司匹林,布洛芬,萘普生,双氯芬酸和塞来昔布等药物。

对于处方使用NSAIDs,FDA建议更改处方信息强调可能导致婴儿的肾脏风险和羊水不足。建议在怀孕20周或以后避免使用NSAIDs,而不是目前NSAIDs处方信息中所述的30周。在约30周时,非甾体抗炎药可能导致未出生婴儿的心脏疾病。

Amniotic fluid and fetal membranes | Radiology Key

图片来源:https://radiologykey.com/amniotic-fluid-and-fetal-membranes/

如果医生认为必须要使用NSAIDs时,应将妊娠20至30周内NSAIDs的使用限制在最低有效剂量,最短持续时间内。如果NSAIDs治疗时间超过48小时,应考虑对羊水进行超声监测。

原始出处:

https://www.firstwordpharma.com/node/1765706?tsid=4

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    2021-07-10 wjywjy
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    2021-02-03 陈吴1243
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    2020-12-09 d830372
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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sun Oct 18 01:28:41 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365651, encodeId=acee136565141, content=<a href='/topic/show?id=41fa21e036' target=_blank style='color:#2F92EE;'>#AIDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2170, encryptionId=41fa21e036, topicName=AIDS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbcc223, createdName=cooco, createdTime=Sun Oct 18 01:28:41 CST 2020, time=2020-10-18, status=1, ipAttribution=)]
    2020-12-06 好啊1990

    正是我需要的知识感谢

    0

  5. 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    2020-10-28 ms7000000479672948

    没积分

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sun Oct 18 01:28:41 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365651, encodeId=acee136565141, content=<a href='/topic/show?id=41fa21e036' target=_blank style='color:#2F92EE;'>#AIDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2170, encryptionId=41fa21e036, topicName=AIDS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbcc223, createdName=cooco, createdTime=Sun Oct 18 01:28:41 CST 2020, time=2020-10-18, status=1, ipAttribution=)]
    2020-10-22 1931

    学习了

    0

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  8. 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  9. 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  10. 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    2020-10-18 cooco

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