J Sex Med:区分早泄和不射精症的大脑功能生物标记研究

2020-10-25 AlexYang MedSci原创

早泄(PE)和不射精症(AJ)是2种相反的男性射精障碍疾病。早泄(PE)和不射精症(AJ)是2种相反的男性射精功能障碍疾病。最近的研究表明,射精过程是由大脑中的某些神经回路介导的。然而,PE和AJ之间

早泄(PE)和不射精症(AJ)是2种相反的男性射精障碍疾病。早泄(PE)和不射精症(AJ)是2种相反的男性射精功能障碍疾病。最近的研究表明,射精过程是由大脑中的某些神经回路介导的。然而,PE和AJ之间的不同机制仍不清楚。

最近,有研究人员采用静息状态功能磁共振成像(fMRI),并通过测量低频波动的幅度(ALFF)来探索PE和AJ患者潜在神经机制。研究包括了17名PE患者、20名AJ患者和23名匹配的健康对照(HC)。研究结果发现,3组患者的ALFF值普遍存在差异,包括左前扣带回、中央前和中央后回、中央旁小叶、颞上回、距状裂、壳核;右中央后回、中央旁小叶、颞中回、壳核。与HC相比,PE患者右额下回(眼球部分)的ALFF更大,AJ患者左中后回的ALFF更大。此外,与AJ患者相比,PE患者在左侧中央盖、前扣带回、下额回(眼眶部分)、壳核和右侧壳核表现出了更大的ALFF,而右侧中央后回的ALFF则减少。更多的是,左侧中央后回、额下回(眼眶部分)、右侧额下回(眼眶部分)的ALFF与PEDT评分呈正相关关系。

大脑区域中两组之间的ALFF差异(PE:早泄;HC:健康对照;AJ:不射精症)

最后,研究人员指出,额叶、顶叶皮层和壳核的ALFF改变可能有助于区分早泄和不射精症。这些脑区的功能异常可能在射精功能障碍患者的生理病理中起到关键作用。

原始出处:

Jianhuai Chen , Jie Yang , Xinfei Huang et al. Brain Functional Biomarkers Distinguishing Premature Ejaculation From Anejaculation by ALFF: A Resting-State fMRI Study. J Sex Med. Oct 2020

 

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    2020-10-25 ms3000000449926787

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