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Gut：CD177+中性粒细胞负性调节IBD！

2017-05-04 xing.T MedSci原创

CD177中性粒细胞负性调节IBD
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由此可见，CD177+中性粒细胞是具有功能活性的亚群，在IBD中通过增加杀菌活性和IL-22的生产来发挥保护作用。针对CD177+中性粒细胞的治疗策略可能有益于IBD的治疗。

中性粒细胞聚集在炎症性肠病(IBD)发炎的肠道粘膜中，在IBD的发病机制中发挥着重要的作用。CD177特异性地表达在中性粒细胞上，并且在炎症期间表达上调。然而，CD177+的中性粒细胞在ISD发病中的作用尚不清楚。

近日，消化病领域权威杂志Gut上发表了一篇研究文章，研究人员采用RT-PCR、流式细胞仪、免疫组织化学等方法检测了IBD患者外周血和肠道黏膜中CD177的表达。研究人员分离出CD177+和CD177-中性粒细胞，采用RNA测序方法确定基因的表达差异。在177-/-和野生型小鼠中通过给予葡聚糖硫酸钠（DSS）建立的结肠炎动物中来确定CD177+中性粒细胞在IBD中的作用。

研究人员发现相比于健康对照者，IBD活动患者外周血和发炎的肠道粘膜中CD177+中性粒细胞明显增加。RNA测序分析表明IBD患者中CD177+和CD177-中性粒细胞之间的基因表达差异与对细菌防御、过氧化氢和活性氧（ROS）的反应相关。CD177+中性粒细胞产生的促炎性细胞因子水平较低（如干扰素γ，白细胞介素（IL）-6，IL-17A），但IL-22和转化生长因子-β水平较高，表现出杀菌活性增加（即活性氧、抗菌肽、中性粒细胞外陷阱），相比于CD177-亚群。与野生型小鼠相比，177-/-小鼠对DSS刺激产生更严重的结肠炎。此外，CD177缺失导致肠道屏障受损，以及通过降低CD177-中性粒细胞IL-22的产生减弱抗菌免疫。

由此可见，CD177+中性粒细胞是具有功能活性的亚群，在IBD中通过增加杀菌活性和IL-22的生产来发挥保护作用。针对CD177+中性粒细胞的治疗策略可能有益于IBD的治疗。

原始出处：

Guangxi Zhou,et al. CD177+ neutrophils as functionally activated neutrophils negatively regulate IBD. Gut. 2017. http://dx.doi.org/10.1136/gutjnl-2016-313535

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    2017-08-15 ms6390871039024434

    #负性调节#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1813364, encodeId=9f9f18133641a, content=<a href='/topic/show?id=099992262d1' target=_blank style='color:#2F92EE;'>#负性调节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92262, encryptionId=099992262d1, topicName=负性调节)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Tue Aug 15 04:51:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195171, encodeId=4ff51951e17b, content=认真学习，把间接经验应用到临床实践中去，然后再总结出新思路。点赞啦！, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon May 08 05:49:13 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194928, encodeId=0cbb19492895, content=学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGYaG3DtvrLVJ7HhIECWX4ll1PfCD3ibABpkrZH09K1t3LBib16Twic4GC4YC5eeQ29w9rDgacd9FSH/0, createdBy=f3ae2037787, createdName=医之美, createdTime=Sun May 07 09:36:48 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263434, encodeId=ebb51263434d6, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sat May 06 03:51:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296633, encodeId=a39b1296633d2, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Sat May 06 03:51:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193866, encodeId=bd5019386624, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Fri May 05 00:06:41 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-08 ylzr123

    认真学习，把间接经验应用到临床实践中去，然后再总结出新思路。点赞啦！

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1813364, encodeId=9f9f18133641a, content=<a href='/topic/show?id=099992262d1' target=_blank style='color:#2F92EE;'>#负性调节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92262, encryptionId=099992262d1, topicName=负性调节)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Tue Aug 15 04:51:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195171, encodeId=4ff51951e17b, content=认真学习，把间接经验应用到临床实践中去，然后再总结出新思路。点赞啦！, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon May 08 05:49:13 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194928, encodeId=0cbb19492895, content=学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGYaG3DtvrLVJ7HhIECWX4ll1PfCD3ibABpkrZH09K1t3LBib16Twic4GC4YC5eeQ29w9rDgacd9FSH/0, createdBy=f3ae2037787, createdName=医之美, createdTime=Sun May 07 09:36:48 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263434, encodeId=ebb51263434d6, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sat May 06 03:51:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296633, encodeId=a39b1296633d2, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Sat May 06 03:51:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193866, encodeId=bd5019386624, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Fri May 05 00:06:41 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-07 医之美

    学习下

    0

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    2017-05-06 bnurmamat

    #IBD#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1813364, encodeId=9f9f18133641a, content=<a href='/topic/show?id=099992262d1' target=_blank style='color:#2F92EE;'>#负性调节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92262, encryptionId=099992262d1, topicName=负性调节)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Tue Aug 15 04:51:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195171, encodeId=4ff51951e17b, content=认真学习，把间接经验应用到临床实践中去，然后再总结出新思路。点赞啦！, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon May 08 05:49:13 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194928, encodeId=0cbb19492895, content=学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGYaG3DtvrLVJ7HhIECWX4ll1PfCD3ibABpkrZH09K1t3LBib16Twic4GC4YC5eeQ29w9rDgacd9FSH/0, createdBy=f3ae2037787, createdName=医之美, createdTime=Sun May 07 09:36:48 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263434, encodeId=ebb51263434d6, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sat May 06 03:51:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296633, encodeId=a39b1296633d2, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Sat May 06 03:51:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193866, encodeId=bd5019386624, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Fri May 05 00:06:41 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-06 yykkxiaodou

    #中性粒细胞#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1813364, encodeId=9f9f18133641a, content=<a href='/topic/show?id=099992262d1' target=_blank style='color:#2F92EE;'>#负性调节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92262, encryptionId=099992262d1, topicName=负性调节)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Tue Aug 15 04:51:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195171, encodeId=4ff51951e17b, content=认真学习，把间接经验应用到临床实践中去，然后再总结出新思路。点赞啦！, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon May 08 05:49:13 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194928, encodeId=0cbb19492895, content=学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuGYaG3DtvrLVJ7HhIECWX4ll1PfCD3ibABpkrZH09K1t3LBib16Twic4GC4YC5eeQ29w9rDgacd9FSH/0, createdBy=f3ae2037787, createdName=医之美, createdTime=Sun May 07 09:36:48 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263434, encodeId=ebb51263434d6, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sat May 06 03:51:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296633, encodeId=a39b1296633d2, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Sat May 06 03:51:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193866, encodeId=bd5019386624, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Fri May 05 00:06:41 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-05 tanxingdoctor

    学习了谢谢分享

    0