Diabetologia:糖尿病相关的自身抗体与哮喘、湿疹和过敏性鼻炎的相关性研究

2020-07-05 AlexYang MedSci原创

最近,有研究人员展现了胰岛素自身抗体、1型糖尿病前体与持续性哮喘、过敏性鼻炎和湿疹之间的关系。

最近,有研究人员展现了胰岛素自身抗体、1型糖尿病前体与持续性哮喘、过敏性鼻炎和湿疹之间的关系。

研究共包括了2159名新生儿,他们的一级亲属患有1型糖尿病,并选择HLA基因型进行随访,直到最小的参与者年满10岁为止。研究发现,特应性湿疹、过敏性鼻炎和持续性哮喘的累积发生率在9-11岁时分别为22%、9%和7.5%。糖尿病相关的自身抗体的产生表现出了与随后报道的哮喘和湿疹的发生存在保护性关系。鼻炎的发生与胰岛素自身抗体(IAA)或者GADA的产生没有显著的关系,但是却表现出与其他有ICA的疾病或多种自身抗体首次同时出现时相同的反向关系。

最后,研究人员指出,他们的发现为特应性疾病与糖尿病相关的自身免疫关系提供了证据,并阐释了对于湿疹,其相互作用取决于哪一种自身抗体首先出现。

原始出处:

Jeffrey P Krischer , David Cuthbertson , Marisa Couluris et al. Association of Diabetes-Related Autoantibodies With the Incidence of Asthma, Eczema and Allergic Rhinitis in the TRIGR Randomised Clinical Trial. Diabetologia. 17 June 2020.

 

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    2021-11-07 1482963am12暂无昵称

    学习了

    0

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    2021-02-16 zhouqu_8
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    2020-07-05 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2020-07-05 医鸣惊人

    学习

    0

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糖尿病患者之所以会出现脚溃烂是因为糖尿病患者的下肢血管和周围神经病变及感染三种因素共同作用下才发生在足部的一种溃烂坏疽现象。

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二甲双胍治疗与肠腔内空间[18F]FDG积累增加有关,表明这种药物促进了葡萄糖从血液循环进入粪便的运输。