Heart:非细菌性血栓性心内膜炎的人口统计学、诊断和结局

2022-05-14 MedSci原创 MedSci原创

非细菌性血栓性心内膜炎多发于女性,临床表现以栓塞并发症最为常见。总体而言,非细菌性血栓性心内膜炎患者预后较差,尤其是那些患有肺癌或转移性肿瘤的患者。

非细菌性血栓性心内膜炎是一种综合征,其特征是由于非感染性原因导致的心脏瓣膜增生和/或增厚。现在,基于超声心动图检查使得非细菌性血栓性心内膜炎的诊断成为可能。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,为了更好地描述这种疾病,研究人员对这些患者的流行病学、人口统计学、诊断和临床结局进行了回顾。

该研究纳入了2014年12月至2021年12月期间在梅奥诊所内所有诊断为非细菌性血栓性心内膜炎的成年人。非细菌性血栓性心内膜炎的诊断至少由两个专业的临床医生来确定,包括心脏病学、传染病学、风湿病学和肿瘤学专家。研究人员排除了血液培养阳性、感染性心内膜炎、心内膜炎培养阴性和研究授权未通过的患者。所有患者均随访1年。

该研究共确定了48例患者,平均年龄为60.0±13.8岁,75%为女性。最常见的合并症是恶性肿瘤(52.1%)和结缔组织病(37.5%)。瓣膜异常包括41例(85.4%)为赘生物,43例(89.6%)为瓣膜增厚,26例(54.2%)为中度至重度返流。38例(79.2%)患者在诊断出非细菌性血栓性心内膜炎后1个月内发生栓塞事件(26例(54.2%)患者发生卒中),16例(33.3%)患者在诊断出非细菌性血栓性心内膜炎后1年内死亡。转移瘤和肺癌与患者1年全因死亡率相关(p=0.0017和p=0.0004)。

由此可见,非细菌性血栓性心内膜炎多发于女性,临床表现以栓塞并发症最为常见。总体而言,非细菌性血栓性心内膜炎患者预后较差,尤其是那些患有肺癌或转移性肿瘤的患者。考虑到非细菌性血栓性心内膜炎的发病率和死亡率,需要对其进行进一步的研究。

原始出处:

Juan A Quintero-Martinez.et al.Contemporary demographics, diagnostics and outcomes in non-bacterial thrombotic endocarditis.heart.2022.https://heart.bmj.com/content/early/2022/05/08/heartjnl-2022-320970

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    2022-05-16 zhaojie88
  5. [GetPortalCommentsPageByObjectIdResponse(id=1708708, encodeId=22d21e087080a, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Fri Feb 03 15:10:31 CST 2023, time=2023-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078196, encodeId=b24820e81966b, content=<a href='/topic/show?id=53cb89101eb' target=_blank style='color:#2F92EE;'>#血栓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89101, encryptionId=53cb89101eb, topicName=血栓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Nov 11 06:10:31 CST 2022, time=2022-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350772, encodeId=f25d1350e72c8, content=<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50878, encryptionId=a32d508e8c3, topicName=心内膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357918, encodeId=ce6d135e918a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442320, encodeId=fc57144232021, content=<a href='/topic/show?id=4989e8938c9' target=_blank style='color:#2F92EE;'>#统计学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78938, encryptionId=4989e8938c9, topicName=统计学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df8a4916199, createdName=siiner, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563612, encodeId=94e7156361274, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1219856, encodeId=e4a71219856b4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77ec5568611, createdName=陈文慧, createdTime=Sun May 15 22:32:36 CST 2022, time=2022-05-15, status=1, ipAttribution=)]
    2022-05-16 siiner
  6. [GetPortalCommentsPageByObjectIdResponse(id=1708708, encodeId=22d21e087080a, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Fri Feb 03 15:10:31 CST 2023, time=2023-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078196, encodeId=b24820e81966b, content=<a href='/topic/show?id=53cb89101eb' target=_blank style='color:#2F92EE;'>#血栓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89101, encryptionId=53cb89101eb, topicName=血栓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Nov 11 06:10:31 CST 2022, time=2022-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350772, encodeId=f25d1350e72c8, content=<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50878, encryptionId=a32d508e8c3, topicName=心内膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357918, encodeId=ce6d135e918a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442320, encodeId=fc57144232021, content=<a href='/topic/show?id=4989e8938c9' target=_blank style='color:#2F92EE;'>#统计学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78938, encryptionId=4989e8938c9, topicName=统计学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df8a4916199, createdName=siiner, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563612, encodeId=94e7156361274, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1219856, encodeId=e4a71219856b4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77ec5568611, createdName=陈文慧, createdTime=Sun May 15 22:32:36 CST 2022, time=2022-05-15, status=1, ipAttribution=)]
    2022-05-16 slcumt
  7. [GetPortalCommentsPageByObjectIdResponse(id=1708708, encodeId=22d21e087080a, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Fri Feb 03 15:10:31 CST 2023, time=2023-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078196, encodeId=b24820e81966b, content=<a href='/topic/show?id=53cb89101eb' target=_blank style='color:#2F92EE;'>#血栓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89101, encryptionId=53cb89101eb, topicName=血栓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Nov 11 06:10:31 CST 2022, time=2022-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350772, encodeId=f25d1350e72c8, content=<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50878, encryptionId=a32d508e8c3, topicName=心内膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357918, encodeId=ce6d135e918a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442320, encodeId=fc57144232021, content=<a href='/topic/show?id=4989e8938c9' target=_blank style='color:#2F92EE;'>#统计学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78938, encryptionId=4989e8938c9, topicName=统计学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df8a4916199, createdName=siiner, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563612, encodeId=94e7156361274, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon May 16 10:10:31 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1219856, encodeId=e4a71219856b4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77ec5568611, createdName=陈文慧, createdTime=Sun May 15 22:32:36 CST 2022, time=2022-05-15, status=1, ipAttribution=)]
    2022-05-15 陈文慧

    学习了

    0

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