SLEEP 2016:嗜睡、疲劳可能是脑老化标志

2016-06-30 Mechront 译 MedSci原创

根据SLEEP 2016年度会议上提出的研究结果,嗜睡和疲劳与认知功能正常的老年脑萎缩有关。罗切斯特梅奥诊所的神经科住院医生Diego Z. Carvalho博士和同事评估了1258例认知功能正常、至少50岁的患者。 在基线时完成MRI和疲劳和嗜睡调查。研究人员还测量了区域皮质厚度和海马体积。Carvalho和同事报告,参与者中有178名患者白天过度疲劳,25名患者临床意义上的疲劳,还有9名患者两

根据SLEEP 2016年度会议上提出的研究结果,嗜睡和疲劳与认知功能正常的老年脑萎缩有关。

罗切斯特梅奥诊所的神经科住院医生Diego Z. Carvalho博士和同事评估了1258例认知功能正常、至少50岁的患者。 在基线时完成MRI和疲劳和嗜睡调查。研究人员还测量了区域皮质厚度和海马体积。

Carvalho和同事报告,参与者中有178名患者白天过度疲劳,25名患者临床意义上的疲劳,还有9名患者两种情况均存在。

结果表明,白天过度嗜睡与较低的全脑皮质厚度有关(–27 µm; 95% CI, –42.9 to –11; P = .001),尤其是颞叶区域与之的联系最紧密,相当于超过3年的老化。疲劳与较低的厚度(–83.7 µm; 95% CI, –138.4 to –28.9; P = .003)和较低的海马体积(–419.2 mm3; 95% CI, –729.3 to –109; P = .008)有关,这些减少分别相当于6岁和.5岁的老化。

“白天过度嗜睡和疲劳的症状与认知能力下降和大脑结构改变有关,尤其是在轻度认知障碍的区域,”研究人员总结说。“我们假设白天过度嗜睡和疲劳症状是脑老化加速的临床标记,这可能与睡眠和医疗合并症有关。”

“我们的研究结果可能有助于在症状出现之前,识别老年痴呆症的易感性或风险人群,以便可以进行早期的干预措施,防止进展为痴呆症。”

原始出处:

Carvalho DZ, et al. Sleepiness and fatigue associated with brain atrophy in cognitively normal elderly: Mayo Clinic study of aging. Presented at: SLEEP Annual Meeting 2016; June 11-15; Denver.

Daytime sleepiness, fatigue may be clinical markers of brain aging.Healio.June 29, 2016

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    2016-10-11 ylzr123

    好文,值得推荐。

    0

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    2016-09-09 1e10c84am36(暂无匿称)

    赞!好文章,拜读,深入学习。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=145989, encodeId=270f14598938, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 22:31:10 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=116868, encodeId=0906116868ab, content=赞!好文章,拜读,深入学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 09 19:54:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106322, encodeId=b923106322ba, content=深度好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Aug 28 15:50:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96053, encodeId=e28b9605363, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160704/IMG577A7DF6CC7185344.jpg, createdBy=07531689549, createdName=早茶月光, createdTime=Fri Aug 05 06:13:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91894, encodeId=27c091894be, content=原来这样, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0f31631005, createdName=保守主义, createdTime=Mon Jul 04 19:03:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260830, encodeId=73131260830ba, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Sat Jul 02 01:08:00 CST 2016, time=2016-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344954, encodeId=0d69134495470, content=<a href='/topic/show?id=cf721640495' target=_blank style='color:#2F92EE;'>#SLE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16404, encryptionId=cf721640495, topicName=SLE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Jul 02 01:08:00 CST 2016, time=2016-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387993, encodeId=01f6138e993a1, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sat Jul 02 01:08:00 CST 2016, time=2016-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91683, encodeId=eeb09168398, content=学习了!这个应当很有根源的,嗜睡就是大脑缺氧的体现, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCYbPBa7AiaIy1pMpp7CF9lHORw4icR9GOrMO6RVNCb1qSUSY9TFBzW5zlrpDia0HKafiarjvcweMaVdg/0, createdBy=cee41716912, createdName=wxsession5a4bd74e, createdTime=Fri Jul 01 09:26:00 CST 2016, time=2016-07-01, status=1, ipAttribution=)]
    2016-08-28 ylzr123

    深度好文,值得学习,赞!

    0

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    2016-08-05 早茶月光

    文章不错

    0

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    2016-07-04 保守主义

    原来这样

    0

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    2016-07-02 tamgche
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    2016-07-02 仁医06
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    2016-07-01 wxsession5a4bd74e

    学习了!这个应当很有根源的,嗜睡就是大脑缺氧的体现

    0

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