Neurology:心血管危险因素对老年人体力活动和大脑完整性标志物之间关联的作用

2022-05-25 Naomi MedSci原创

体育活动与痴呆风险降低有关,但这种关联的机制仍有待确定。近日,研究人员发现,体力活动和大脑灰体积之间的关联是由胰岛素水平和 BMI 的变化介导的。相反,与脑葡萄糖代谢的关联似乎与心血管危险因素无关。

体育活动与痴呆风险降低有关,但这种关联的机制仍有待确定。近日,研究人员试图评估心血管危险因素是否介导老年人体力活动与大脑完整性标志物之间的关联。

在基线时,Age-Well 研究的参与者完成了一份体力活动问卷并收集了心血管危险因素(收缩压、体重指数 [BMI]、当前吸烟状况、高密度脂蛋白胆固醇、总胆固醇和胰岛素水平) ) 和多模式神经影像学(结构 MRI、弥散 MRI、FDG-PET 和 florbetapir PET)。进行多元回归以评估身体活动、心血管危险因素和神经影像学之间的关联。进行中介分析以测试心血管危险因素是否介导了身体活动和神经影像学之间的关联。

  • 共纳入 134 名认知未受损的老年人(≥65 岁)。
  • 较高的体力活动与较高的灰质 (GM) 体积 (β = 0.174, p = 0.030) 和脑葡萄糖代谢 (β = 0.247, p= 0.019)但不伴有淀粉样蛋白沉积或白质完整性。
  • 较高的体力活动与较低的胰岛素水平和 BMI 相关,但与其他心血管危险因素无关。
  • 较低的胰岛素水平和 BMI 与较高的 GM 体积有关,但与脑葡萄糖代谢无关。
  • 在控制胰岛素水平和 BMI 时,体力活动与脑葡萄糖代谢之间的关联保持不变,而与 GM 体积的关联则消失了。
  • 当在同一模型中输入胰岛素水平和 BMI 时,只有 BMI 仍然是 GM 体积的重要预测指标。
  • 中介分析证实,胰岛素水平和 BMI 介导了体力活动和 GM 体积之间的关联。
  • 在阿尔茨海默病敏感区域内重复了分析,结果总体上保持相似。

体力活动和 GM 体积之间的关联是由胰岛素水平和 BMI 的变化介导的。相反,与脑葡萄糖代谢的关联似乎与心血管危险因素无关。从事体育活动的老年人通过维持较低的 BMI 和胰岛素水平来体验心血管益处,从而提高大脑结构的完整性。这项研究对了解身体活动如何影响大脑健康具有重要意义,并可能有助于制定预防或延缓与年龄相关的衰退的策略。

文献来源:Felisatti F, Gonneaud J, Palix C, et al. Role of Cardiovascular Risk Factors on the Association Between Physical Activity and Brain Integrity Markers in Older Adults. Neurology. 2022;98(20):e2023-e2035. doi:10.1212/WNL.0000000000200270

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    2023-01-24 yinhl1978
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    2022-05-25 ms6000001791212108

    学习了,很多疾病与血管疾病,糖代谢异常,不良生活习惯比如吸烟🚬正相关

    0

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