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J Clin Invest：ω-3多不饱和脂肪酸能够改善1型糖尿病和自身免疫！

2017-04-08 MedSci MedSci原创

ω-3多不饱和脂肪酸糖尿病
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尽管胰岛素的益处多多，但是封锁自身免疫的攻击以及胰岛细胞的再生是完全治愈1型糖尿病（T1D）的最终目标。长期摄入ω-3多不饱和脂肪酸（PUFA）可以抑制炎症过程，这就使得这些脂肪酸成为预防和改善自身免疫性疾病的候选药物。近期，一项发表在杂志J Clin Invest上的研究探讨了ω-3 PUFA对T1D的预防和治疗作用。此项研究发现在NOD小鼠中，予以ω-3 PUFA的饮食可以使T1D的发生率急剧

尽管胰岛素的益处多多，但是封锁自身免疫的攻击以及胰岛细胞的再生是完全治愈1型糖尿病（T1D）的最终目标。


长期摄入ω-3多不饱和脂肪酸（PUFA）可以抑制炎症过程，这就使得这些脂肪酸成为预防和改善自身免疫性疾病的候选药物。

近期，一项发表在杂志J Clin Invest上的研究探讨了ω-3 PUFA对T1D的预防和治疗作用。

此项研究发现在NOD小鼠中，予以ω-3 PUFA的饮食可以使T1D的发生率急剧下降，调节Th细胞和Treg的分化，降低IFN-γ、IL-17、IL-6和TNF-α的水平。ω-3 PUFA对来自人外周血单核细胞分离的CD4 + T细胞的分化也产生相似的作用。

CD4 + T细胞分化的调节至少部分通过ω-3 PUFA类二十烷酸衍生物和mTOR复合物1（mTORC1）的抑制介导。

重要的是，在NOD小鼠中通过营养补充或慢病毒介导的ω-3脂肪酸脱氢酶，mfat-1，进行治疗干预，血糖和胰岛素水平恢复正常至少需要182天；阻止了自身免疫的发展，阻止淋巴细胞向再生胰岛细胞的浸润，并大大提高β细胞标志物胰腺和十二指肠同源异型盒1（Pdx1）和配对盒4（Pax4）的表达。

此项研究结果表明ω-3 PUFA可能成为改善T1D的新方法。

原始出处：
Bi X, Li F, et al. ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity. J Clin Invest. 2017 Apr 4. pii: 87388. doi: 10.1172/JCI87388.

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    2017-04-10 12498ca5m92暂无昵称

    #不饱和脂肪酸#

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    2017-06-02 xiangyuzhou971

    #EST#

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    2018-02-15 wwzzly

    #饱和脂肪酸#

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createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 09 21:26:47 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186235, encodeId=6fc118623569, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Sun Apr 09 18:12:40 CST 2017, time=2017-04-09, status=1, ipAttribution=)]
    2018-03-24 quxin068

    #3多不饱和脂肪酸#

    0

  5. 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    2017-10-25 quxin068

    #3多不饱和脂肪酸#

    0

  6. 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    2017-04-10 zll0625

    #多不饱和脂肪酸#

    0

  7. 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createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 09 21:26:47 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186235, encodeId=6fc118623569, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Sun Apr 09 18:12:40 CST 2017, time=2017-04-09, status=1, ipAttribution=)]
    2017-04-10 millore

    #ω-3多不饱和脂肪酸#

    0

  8. 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    2017-04-10 斯嘉莉

    #饱和脂肪#

    0

  9. 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createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 09 21:26:47 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186235, encodeId=6fc118623569, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Sun Apr 09 18:12:40 CST 2017, time=2017-04-09, status=1, ipAttribution=)]
    2017-04-09 虈亣靌

    不错的方式，努力学习，刻苦专研，不断总结出来新经验。

    0

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GetPortalCommentsPageByObjectIdResponse(id=1579969, encodeId=027f15e996949, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Mon Apr 10 03:15:00 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186260, encodeId=8876186260b8, content=不错的方式，努力学习，刻苦专研，不断总结出来新经验。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 09 21:26:47 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186235, encodeId=6fc118623569, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Sun Apr 09 18:12:40 CST 2017, time=2017-04-09, status=1, ipAttribution=)]
    2017-04-09 绛珠草小姐

    学习了，谢谢

    0

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