Stroke:d-二聚体水平可作为来源不明的栓塞性卒中患者复发的预测因子

2021-05-11 MedSci原创 MedSci原创

d-二聚体水平可以作为预测来源不明的卒中患者复发性卒中,尤其是栓塞性缺血性卒中有用的风险评估生物标志物。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,这项研究旨在明确d-二聚体水平在预测来源不明的栓塞性卒中患者复发性卒中中的价值。研究人员还根据d-二聚体水平评估了复发性卒中的潜在原因。

本研究共纳入了1431例来源不明的卒中患者,并根据基线血浆d-二聚体水平分为四分位数。该研究的主要结局指标是卒中事件发生后第二年发生复发性卒中(缺血性或出血性)。

复发性卒中的风险随着d-二聚体四分位数的增加而显着增加(log-rank P=0.001)。d-二聚体四分位数较高的患者因隐性房颤、隐匿性恶性肿瘤或来源不明而发生复发性栓塞性卒中的可能性更高。d-二聚体水平在第3和第4四分位数范围的患者中,大多数复发性卒中为栓塞性卒中,但在第1和第2四分位数范围的患者中并非如此。

d-二聚体预测复发性卒中

多因素分析显示,与第1四分位数范围的患者相比,第3和第4四分位数患者复发性卒中的风险显著增加(风险比为3.12 [95%CI为1.07-9.07],P=0.036;风险比为7.29 [95%CI为2.59-20.52],P<0.001;趋势P<0.001)。二元分析显示,高于正常范围内较高的d-二聚体水平与复发性卒中的风险之间存在显著相关性(风险比为2.48 [95%CI为1.31-4.70],P=0.005)。在亚组分析中,男性较高的d-二聚体水平与复发性卒中的风险明显高于女性(P=0.039)。

由此可见,d-二聚体水平可以作为预测来源不明的卒中患者复发性卒中,尤其是栓塞性缺血性卒中有用的风险评估生物标志物

原始出处:

Kang-Ho Choi.et al.d-dimer Level as a Predictor of Recurrent Stroke in Patients With Embolic Stroke of Undetermined Source.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.032773

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    2021-09-02 hxj0117
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1950391, encodeId=c522195039177, content=<a href='/topic/show?id=bfc624041dc' target=_blank style='color:#2F92EE;'>#二聚体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24041, encryptionId=bfc624041dc, topicName=二聚体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac59108, createdName=hxj0117, createdTime=Thu Sep 02 18:29:21 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720385, encodeId=87b11e20385ad, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Mon Nov 01 18:29:21 CST 2021, time=2021-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310763, encodeId=36431310e634f, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Thu May 13 09:29:21 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310867, encodeId=de97131086e0e, content=<a href='/topic/show?id=b15c5628e9' target=_blank style='color:#2F92EE;'>#D-二聚体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5628, encryptionId=b15c5628e9, topicName=D-二聚体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e093393, createdName=luwei00, createdTime=Thu May 13 09:29:21 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536290, encodeId=9adf15362903c, content=<a href='/topic/show?id=87ec6201043' target=_blank style='color:#2F92EE;'>#栓塞性卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62010, encryptionId=87ec6201043, topicName=栓塞性卒中)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5012676127, createdName=jiekemin, createdTime=Thu May 13 09:29:21 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026850, encodeId=4f18102685068, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue May 11 21:29:21 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964725, encodeId=b767964e25ed, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce514890047, createdName=28154314, createdTime=Tue May 11 21:18:25 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964686, encodeId=2f2b964686d6, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22885498570, createdName=ms7000000313175443, createdTime=Tue May 11 19:30:18 CST 2021, time=2021-05-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1950391, encodeId=c522195039177, content=<a href='/topic/show?id=bfc624041dc' target=_blank style='color:#2F92EE;'>#二聚体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24041, encryptionId=bfc624041dc, topicName=二聚体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac59108, createdName=hxj0117, createdTime=Thu Sep 02 18:29:21 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720385, encodeId=87b11e20385ad, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Mon Nov 01 18:29:21 CST 2021, time=2021-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310763, encodeId=36431310e634f, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Thu May 13 09:29:21 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310867, encodeId=de97131086e0e, content=<a href='/topic/show?id=b15c5628e9' target=_blank style='color:#2F92EE;'>#D-二聚体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5628, encryptionId=b15c5628e9, topicName=D-二聚体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e093393, createdName=luwei00, createdTime=Thu May 13 09:29:21 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536290, encodeId=9adf15362903c, content=<a href='/topic/show?id=87ec6201043' target=_blank style='color:#2F92EE;'>#栓塞性卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62010, encryptionId=87ec6201043, topicName=栓塞性卒中)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5012676127, createdName=jiekemin, createdTime=Thu May 13 09:29:21 CST 2021, time=2021-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026850, encodeId=4f18102685068, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue May 11 21:29:21 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964725, encodeId=b767964e25ed, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce514890047, createdName=28154314, createdTime=Tue May 11 21:18:25 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964686, encodeId=2f2b964686d6, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22885498570, createdName=ms7000000313175443, createdTime=Tue May 11 19:30:18 CST 2021, time=2021-05-11, status=1, ipAttribution=)]
    2021-05-11 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2021-05-11 28154314

    值得学习

    0

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    2021-05-11 ms7000000313175443

    0

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