BMJ:SGLT-2抑制剂或GLP-1受体激动剂治疗糖尿病的临床优势

2021-01-15 MedSci原创 MedSci原创

SGLT-2抑制剂和GLP-1受体激动剂可降低糖尿病患者的心血管及肾脏事件风险

钠-葡萄糖共转运蛋白-2(SGLT-2)抑制剂和胰高血糖素样肽-1(GLP-1)受体激动剂是临床上广泛使用的糖尿病药物,除良好的血糖控制效果之外,其具有传统糖尿病治疗药物不具备的降低糖尿病患者血管死亡率和非致命性心血管并发症风险的优势。近日研究人员比较了二者对不同心血管及肾脏风险糖尿病患者的治疗效果差异
 
本次研究为系统综述及荟萃分析,收集截至2020年8月11日Medline, Embase和Cochrane CENTRAL的相关研究数据,入选标准为比较SGLT-2抑制剂或GLP-1受体激动剂与安慰剂、标准护理或其他降糖治疗,用于成人II型糖尿病的临床对照研究,持续时间至少24周。患者5年内的心血管风险分为极低(无风险因素)、低(3个以上风险因素)、中等(患有心血管疾病)、高(患有慢性肾病)以及极高(同时患有心血管疾病和慢性肾病)5个层次。
 
764个研究,纳入本次荟萃分析,总计包含421346名患者。SGLT-2抑制剂和GLP-1受体激动剂可降低糖尿病患者全因死亡、心血管死亡、非致命性心肌梗塞以及肾衰竭风险。研究发现,SGLT-2抑制剂在降低心衰住院和死亡率方面的效果优于GLP-1受体激动剂;而GLP-1受体激动剂在降低非致命性中风方面的效果优于SGLT-2抑制剂,但SGLT-2抑制剂具有较高的尿路感染风险,而GLP-1受体激动剂的胃肠道事件风险较高。有证据表明,SGLT-2抑制剂和GLP-1受体激动剂对改善患者体重有益,但在降低糖尿病并发症方面,如截肢、失明、眼病、神经痛或与健康相关的生活质量方面无显著优势。
 
研究认为,SGLT-2抑制剂和GLP-1受体激动剂可降低糖尿病患者的心血管及肾脏事件风险
 
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    2021-09-21 gaoxiaoe
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  4. 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&lt;a href="https://1680380.com/view/shiyix5_sd/index.html"&gt;十一运夺金&lt;/a&gt; &lt;a href="https://1680380.com/view/shishicai_xy/ssc_index.html"&gt;幸运时时彩&lt;/a&gt;, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84225464811, createdName=lesliehuang, createdTime=Wed Mar 10 16:35:50 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921929, encodeId=0d4b92192904, content=感谢分享新药, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b355457759, createdName=ms7000002141506965, createdTime=Mon Feb 01 15:17:19 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921936, encodeId=4ece9219362a, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>减肥的药心血管获益都不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210131/b35591bafe2a4b869917b577adba9fab/c267322e38334bd6a95a8340ea85f70c.jpg, createdBy=f36b1426385, createdName=6322400001, createdTime=Mon Feb 01 15:29:00 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294040, encodeId=1d5412940404a, content=<a href='/topic/show?id=bb0e8081b2' target=_blank style='color:#2F92EE;'>#GLP-1受体激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8081, encryptionId=bb0e8081b2, topicName=GLP-1受体激动剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e183245, createdName=Eleven11, createdTime=Sun Jan 17 02:29:22 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
    2021-05-21 jklm09
  5. 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  6. 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&lt;a href="https://1680380.com/view/shiyix5_sd/index.html"&gt;十一运夺金&lt;/a&gt; &lt;a href="https://1680380.com/view/shishicai_xy/ssc_index.html"&gt;幸运时时彩&lt;/a&gt;, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84225464811, createdName=lesliehuang, createdTime=Wed Mar 10 16:35:50 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921929, encodeId=0d4b92192904, content=感谢分享新药, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b355457759, createdName=ms7000002141506965, createdTime=Mon Feb 01 15:17:19 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921936, encodeId=4ece9219362a, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>减肥的药心血管获益都不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210131/b35591bafe2a4b869917b577adba9fab/c267322e38334bd6a95a8340ea85f70c.jpg, createdBy=f36b1426385, createdName=6322400001, createdTime=Mon Feb 01 15:29:00 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294040, encodeId=1d5412940404a, content=<a href='/topic/show?id=bb0e8081b2' target=_blank style='color:#2F92EE;'>#GLP-1受体激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8081, encryptionId=bb0e8081b2, topicName=GLP-1受体激动剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e183245, createdName=Eleven11, createdTime=Sun Jan 17 02:29:22 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
    2021-11-25 tulenzi
  7. [GetPortalCommentsPageByObjectIdResponse(id=1849164, encodeId=576318491641e, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Sep 21 22:29:22 CST 2021, time=2021-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995626, encodeId=2af21995626db, content=<a href='/topic/show?id=992411149e' target=_blank style='color:#2F92EE;'>#2抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1114, encryptionId=992411149e, topicName=2抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28b7142, createdName=liuquan, createdTime=Fri Jun 11 18:29:22 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793914, encodeId=93981e9391494, content=<a href='/topic/show?id=722516221ec' target=_blank style='color:#2F92EE;'>#SGLT-2抑制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16221, encryptionId=722516221ec, topicName=SGLT-2抑制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=052a130, createdName=yyj062, createdTime=Sun Nov 14 07:29:22 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852581, encodeId=fee71852581b4, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri May 21 05:29:22 CST 2021, time=2021-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081984, encodeId=a032208198423, content=<a href='/topic/show?id=acf116218e6' target=_blank style='color:#2F92EE;'>#SGLT-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16218, encryptionId=acf116218e6, topicName=SGLT-2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a3a2500014, createdName=fmq_28614553, createdTime=Sat Apr 10 14:29:22 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793855, encodeId=ee671e9385570, content=<a href='/topic/show?id=5a3f1621e7d' target=_blank style='color:#2F92EE;'>#SGLT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16217, encryptionId=5a3f1621e7d, topicName=SGLT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Thu Nov 25 23:29:22 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947159, encodeId=a3f594e15946, content=&lt;a href="https://www.1680380.com/view/xingyft/pk10kai.html"&gt;幸运飞艇&lt;/a&gt; &lt;a href="https://1680380.com/view/shiyix5_sd/index.html"&gt;十一运夺金&lt;/a&gt; &lt;a href="https://1680380.com/view/shishicai_xy/ssc_index.html"&gt;幸运时时彩&lt;/a&gt;, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84225464811, createdName=lesliehuang, createdTime=Wed Mar 10 16:35:50 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921929, encodeId=0d4b92192904, content=感谢分享新药, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b355457759, createdName=ms7000002141506965, createdTime=Mon Feb 01 15:17:19 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921936, encodeId=4ece9219362a, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>减肥的药心血管获益都不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210131/b35591bafe2a4b869917b577adba9fab/c267322e38334bd6a95a8340ea85f70c.jpg, createdBy=f36b1426385, createdName=6322400001, createdTime=Mon Feb 01 15:29:00 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294040, encodeId=1d5412940404a, content=<a href='/topic/show?id=bb0e8081b2' target=_blank style='color:#2F92EE;'>#GLP-1受体激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8081, encryptionId=bb0e8081b2, topicName=GLP-1受体激动剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e183245, createdName=Eleven11, createdTime=Sun Jan 17 02:29:22 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
    2021-03-10 lesliehuang

    <a href="https://www.1680380.com/view/xingyft/pk10kai.html">幸运飞艇</a> <a href="https://1680380.com/view/shiyix5_sd/index.html">十一运夺金</a> <a href="https://1680380.com/view/shishicai_xy/ssc_index.html">幸运时时彩</a>

    0

  8. 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&lt;a href="https://1680380.com/view/shiyix5_sd/index.html"&gt;十一运夺金&lt;/a&gt; &lt;a href="https://1680380.com/view/shishicai_xy/ssc_index.html"&gt;幸运时时彩&lt;/a&gt;, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84225464811, createdName=lesliehuang, createdTime=Wed Mar 10 16:35:50 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921929, encodeId=0d4b92192904, content=感谢分享新药, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b355457759, createdName=ms7000002141506965, createdTime=Mon Feb 01 15:17:19 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921936, encodeId=4ece9219362a, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>减肥的药心血管获益都不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210131/b35591bafe2a4b869917b577adba9fab/c267322e38334bd6a95a8340ea85f70c.jpg, createdBy=f36b1426385, createdName=6322400001, createdTime=Mon Feb 01 15:29:00 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294040, encodeId=1d5412940404a, content=<a href='/topic/show?id=bb0e8081b2' target=_blank style='color:#2F92EE;'>#GLP-1受体激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8081, encryptionId=bb0e8081b2, topicName=GLP-1受体激动剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e183245, createdName=Eleven11, createdTime=Sun Jan 17 02:29:22 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
    2021-02-01 ms7000002141506965

    感谢分享新药

    0

  9. 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&lt;a href="https://1680380.com/view/shiyix5_sd/index.html"&gt;十一运夺金&lt;/a&gt; &lt;a href="https://1680380.com/view/shishicai_xy/ssc_index.html"&gt;幸运时时彩&lt;/a&gt;, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84225464811, createdName=lesliehuang, createdTime=Wed Mar 10 16:35:50 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921929, encodeId=0d4b92192904, content=感谢分享新药, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b355457759, createdName=ms7000002141506965, createdTime=Mon Feb 01 15:17:19 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921936, encodeId=4ece9219362a, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>减肥的药心血管获益都不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210131/b35591bafe2a4b869917b577adba9fab/c267322e38334bd6a95a8340ea85f70c.jpg, createdBy=f36b1426385, createdName=6322400001, createdTime=Mon Feb 01 15:29:00 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294040, encodeId=1d5412940404a, content=<a href='/topic/show?id=bb0e8081b2' target=_blank style='color:#2F92EE;'>#GLP-1受体激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8081, encryptionId=bb0e8081b2, topicName=GLP-1受体激动剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e183245, createdName=Eleven11, createdTime=Sun Jan 17 02:29:22 CST 2021, time=2021-01-17, status=1, ipAttribution=)]
    2021-02-01 6322400001

    #糖尿病#减肥的药心血管获益都不错

    0

  10. 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