Hypertension:白大衣高血压孕妇围产期母婴结局

2020-05-27 MedSci原创 MedSci原创

在高血压孕妇中应确诊WCH。确诊后,这些妇女需要监测子痫前期、小胎龄儿和早产的发生。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,这项荟萃分析旨在调查白大衣高血压(WCH)是否对孕妇、胎儿和新生儿结局产生不利影响。

研究人员检索了Medline、EMBASE、www.Clinicaltrials.gov和Cochrane图书馆数据库,检索时间截止至2019年12月。研究人员比较了WCH、血压正常、慢性高血压、妊娠高血压或任何妊娠高血压疾病孕妇的结局。

十二项研究符合纳入系统评价的条件。入组时孕周少于20周的WCH孕妇发生子痫前期风险显著增加(合并风险比[RR]为5.43 [95%CI为2.00–14.71])。此外,WCH孕妇分娩小于胎龄新生儿(RR为2.47 [95%CI为1.21-5.05],P=0.013)和早产(RR为2.86 [95%CI为1.44–5.68],P=0.002])的风险增加。与妊娠高血压妇女相比,WCH孕妇子痫前期(风险比为0.43[95%CI为0.23-0.78],P=0.005)、小胎龄儿(RR为0.46 [95%CI为0.26-0.82],P=0.008)、早产(RR为0.47 [95%CI为0.31-0.71],P<0.001)风险显著降低。与慢性高血压妇女相比,WCH妇女分娩约晚1周(平均差异为1.06周[95%CI为0.44–1.67]; P<0.001)。与正常血压相比,WCH与较差的围产期和产妇预后相关,但与妊娠高血压和慢性高血压相比,预后较好。

因此,在高血压孕妇中应确诊WCH。确诊后,这些妇女需要监测子痫前期、小胎龄儿和早产的发生。

原始出处:

Sonia Johnson.et al.Maternal and Perinatal Outcomes of White Coat Hypertension During Pregnancy A Systematic Review and Meta-Analysis.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14627

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    2020-07-07 feather89
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    2020-05-29 zhouqu_8
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