JAMA Surg:吲哚菁绿成像可提高胃癌切除患者淋巴结清扫效果

2020-03-02 MedSci MedSci原创

研究发现吲哚菁绿成像可显著提高D2淋巴结切除术患者的淋巴结清扫效果,可用于腹腔镜胃切除术,特别是全胃切除术中常规淋巴结成像

近日研究人员考察了腹腔镜吲哚菁绿(ICG)成像D2淋巴腺切除术对癌患者的安全性和有效性。

临床肿瘤分期cT1-cT4a, N0/+,M0,可切除腺癌患者参与研究,随机接受ICG或非ICG成像切除。ICG组在术前1天接受内镜下ICG瘤周粘膜下层注射,随后通过近红外成像进行腹腔镜胃切除术。研究的主要终点为检测到的淋巴结总数。

266名患者参与研究,133人接受了ICG示踪引导的腹腔镜胃切除术,133人接受了常规腹腔镜胃切除术,258名患者被纳入改良意向治疗分析,其中ICG组129名患者(86名男性和43名女性;平均[SD]年龄,57.8[10.7]岁),非ICG组129名患者(87名男性和42名女性;平均[SD]年龄,60.1[9.1]岁)。在ICG组中检测到的平均淋巴结数显著高于非ICG组(淋巴结数:50.5[15.9] vs 42.0[10.3];P?<0.001)。ICG组检测到的胃周和胃外淋巴结明显多于非ICG组。在D2淋巴结切除范围内,ICG组的平均淋巴结总数也明显高于非ICG组(平均[SD],49.6[15.0]淋巴结 vs  41.7[10.2]淋巴结;P<0.001)。组间术后恢复过程相近,ICG组与非ICG组在术后30天内并发症的发生率分别为15.5% 和16.3% ,严重程度无显著性差异。

研究发现吲哚菁绿成像可显著提高D2淋巴结切除术患者的淋巴结清扫效果,可用于腹腔镜胃切除术,特别是全胃切除术中常规淋巴结成像。

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    2020-03-04 sodoo
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    2020-03-02 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1973349, encodeId=876d19e334929, content=<a href='/topic/show?id=b7d8660203a' target=_blank style='color:#2F92EE;'>#淋巴结清扫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66020, encryptionId=b7d8660203a, topicName=淋巴结清扫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac782500066, createdName=12498768m13(暂无昵称), createdTime=Tue Jan 12 05:08:00 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056770, encodeId=90f82056e70d6, content=<a href='/topic/show?id=027b39328ad' target=_blank style='color:#2F92EE;'>#吲哚菁绿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39328, encryptionId=027b39328ad, topicName=吲哚菁绿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Mon Jan 18 03:08:00 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293089, encodeId=31b81293089db, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Wed Mar 04 10:08:00 CST 2020, time=2020-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035941, encodeId=cb561035941d4, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon Mar 02 22:08:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047006, encodeId=2417104e00675, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Mar 02 22:08:00 CST 2020, time=2020-03-02, status=1, ipAttribution=)]
    2020-03-02 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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