Nutrients:高蛋白卡路里限制饮食改变了肥胖症患者的肠道微生物群

2021-07-28 MedSci原创 MedSci原创

高蛋白卡路里限制饮食对肥胖症有临床疗效,但其机制还不完全清楚。肠道微生物组是肥胖症的媒介,临床前数据支持高蛋白饮食(HPD)对肥胖症肠道微生物组的影响,但对人类的研究很少。

高蛋白卡路里限制饮食对肥胖症有临床疗效,但其机制还不完全清楚。肠道微生物组是肥胖症的媒介,临床前数据支持高蛋白饮食(HPD)对肥胖症肠道微生物组的影响,但对人类的研究很少。

为了解决这个问题,研究人员对80名超重和肥胖的受试者进行了饮食干预试验,随机分配到限制热量的高蛋白饮食(HPD)(30%的热量摄入)或限制热量的正常蛋白饮食(NPD)(15%)8周。使用饮食史调查表III评估基线饮食摄入模式。在基线、第1周、第2周、第4周、第6周和第8周进行纵向粪便采样,共365份样本。肠道微生物组的组成通过16S rRNA基因测序进行评估。

结果显示,基线时,微生物组成与纤维和蛋白质摄入有关。与NPD的受试者相比,HPD的受试者显示微生物多样性的显著增加。与NPD相比,HPD也与治疗后微生物组成的显著差异有关。与基线相比,两种饮食都引起了微生物种类的变化,包括阿克曼氏菌和双歧杆菌的富集和普雷沃特氏菌的枯竭。

 

综上,这些发现提供了证据,证明减肥饮食改变了肥胖症的肠道微生物组,并表明与NPD相比,HPD的影响不同,这可能影响HPD的临床反应。

 

原始出处:

 

Tien S Dong, et al., A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity. Nutrients. 2020 Oct 21;12(10):3221. doi: 10.3390/nu12103221.

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    2021-07-30 海豹
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    2021-07-28 周小洋

    非常有意思,这对于肥胖患者很有帮助

    0

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    2021-07-28 95246619

    非常有用的文章,不错

    0

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