Chest:空气污染与特发性肺纤维化患者住院之间的关联

2020-02-22 xing.T MedSci原创

该研究的结果表明,空气污染的急剧增加是对主要诊断为IPF的患者住院的危险因素。

特发性肺纤维化(IPF)在数年内导致进行性呼吸困难、低氧血症和死亡。关于空气污染对疾病恶化的影响知之甚少。

近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员利用分布在智利圣地亚哥七个城市中心的七个空气监测站的环境空气污染和气候数据,以及2001年至2012年的每日患者住院数据,IPF在国际疾病分类(第10版)中的代码为J84.1。研究人员使用广义线性模型旨在评估每日环境空气污染与每日J84.1住院人数之间的线性关系。

所有区域的平均污染物水平如下:一氧化碳(CO)为0.96 ppm,臭氧(O3)为64 ppb,二氧化氮(NO2)为43 ppb,二氧化硫(SO2)为9 ppb,直径<2.5μm的颗粒物(PM2.5)为29μg/m3,直径小于10μm的颗粒物(PM10)为67μg/m3。对于圣地亚哥地区,调整了年龄、性别和天气后,所有污染物(臭氧除外)所致的J84.1住院治疗的相对风险估计值具有统计学意义。在两种污染物的模型中,尽管对每个其他测量的污染物进行了调整,但NO2和PM10的显著性仍然存在。

该研究的结果表明,空气污染的急剧增加是对主要诊断为IPF的患者住院的危险因素。

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    2020-11-09 Smile2680
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    2020-02-22 天地飞扬

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