Eur Arch Otorhinolaryngol:特发性突聋患者治疗后的听力结果预测

2022-02-08 AlexYang MedSci原创

为每个频率的听力结果分别构建了一个多元回归模型,尝试实现对ISSNHL的实际预测。

特发性突聋(ISSNHL)并不是一种特殊的疾病实体,而被认为是内耳中各种病理状况的临床表现。循环系统紊乱、病毒感染、迷路膜破裂和自身免疫反应都是可能的病因。由于ISSNHL的病因不明确,而且有许多不同的治疗方案,该疾病的听力结果一般很难预测

近期,来自日本的研究人员在《Eur Arch Otorhinolaryngol》上发表文章,他们为每个频率的听力结果分别构建了一个多元回归模型,尝试实现对ISSNHL的实际预测

研究招募了2015年-2020年在研究人员所在科治疗的235名连续的ISSNHL住院患者(250-4000Hz的平均听力水平≥40dB;从发病到治疗的时间≤14天;126名男性/109名女性;年龄范围17-87岁(平均61.0岁))。所有患者都接受了全身泼尼松龙的治疗,并联合使用了地塞米松的耳内注射治疗。在治疗前(HLpre)和治疗后(HLpost),在每个倍频程测量了125-8000Hz的纯音听阈。使用了五个解释变量(年龄、从发病到治疗的天数、是否有眩晕、HLpre和对侧耳朵的听力水平)为HLpost(因变量)建立了一个多元回归模型

结果发现,多重相关系数随着频率的增加而增加。在高频率下有很强的相关性,4000/8000Hz的多重相关系数为0.784/0.830。与中低频相比,4000/8000Hz的70%预测区间宽度更窄(±18.2/16.3 dB)。在五个解释变量中,任何频率下HLpre都显示出了最大的偏相关系数。HLpre的偏相关系数随着频率的增加而增加,可能部分地解释了高频率下的高多重相关系数。

HLpost和5个解释变量的偏相关系数情况

 

综上所述,他们的模型对预测ISSNHL患者的高频听力结果有着实际用途

 

原始出处:

Yuki Kawamura, Hideaki Suzuki, Thi Nga Nguyen et al. Frequency-specific prediction model of hearing outcomes in patients with idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol. Jan 2022.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1894838, encodeId=61db189483821, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Wed Mar 09 09:16:56 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022320, encodeId=6efd2022320b8, content=<a href='/topic/show?id=b4e43926560' target=_blank style='color:#2F92EE;'>#听力结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39265, encryptionId=b4e43926560, topicName=听力结果)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Jan 07 20:16:56 CST 2023, time=2023-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306721, encodeId=987a1306e2124, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Feb 10 02:16:56 CST 2022, time=2022-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191167, encodeId=4249119116e31, content=很感兴趣的一个方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e831560211, createdName=ZYY7209, createdTime=Tue Feb 08 20:11:02 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191111, encodeId=7e7311911115b, content=内容祥实,, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89ae6481716, createdName=ms3000000637975859, createdTime=Tue Feb 08 18:35:09 CST 2022, time=2022-02-08, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1894838, encodeId=61db189483821, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Wed Mar 09 09:16:56 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022320, encodeId=6efd2022320b8, content=<a href='/topic/show?id=b4e43926560' target=_blank style='color:#2F92EE;'>#听力结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39265, encryptionId=b4e43926560, topicName=听力结果)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Jan 07 20:16:56 CST 2023, time=2023-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306721, encodeId=987a1306e2124, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Feb 10 02:16:56 CST 2022, time=2022-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191167, encodeId=4249119116e31, content=很感兴趣的一个方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e831560211, createdName=ZYY7209, createdTime=Tue Feb 08 20:11:02 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191111, encodeId=7e7311911115b, content=内容祥实,, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89ae6481716, createdName=ms3000000637975859, createdTime=Tue Feb 08 18:35:09 CST 2022, time=2022-02-08, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1894838, encodeId=61db189483821, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Wed Mar 09 09:16:56 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022320, encodeId=6efd2022320b8, content=<a href='/topic/show?id=b4e43926560' target=_blank style='color:#2F92EE;'>#听力结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39265, encryptionId=b4e43926560, topicName=听力结果)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Jan 07 20:16:56 CST 2023, time=2023-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306721, encodeId=987a1306e2124, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Feb 10 02:16:56 CST 2022, time=2022-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191167, encodeId=4249119116e31, content=很感兴趣的一个方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e831560211, createdName=ZYY7209, createdTime=Tue Feb 08 20:11:02 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191111, encodeId=7e7311911115b, content=内容祥实,, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89ae6481716, createdName=ms3000000637975859, createdTime=Tue Feb 08 18:35:09 CST 2022, time=2022-02-08, status=1, ipAttribution=)]
    2022-02-10 ysjykql
  4. [GetPortalCommentsPageByObjectIdResponse(id=1894838, encodeId=61db189483821, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Wed Mar 09 09:16:56 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022320, encodeId=6efd2022320b8, content=<a href='/topic/show?id=b4e43926560' target=_blank style='color:#2F92EE;'>#听力结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39265, encryptionId=b4e43926560, topicName=听力结果)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Jan 07 20:16:56 CST 2023, time=2023-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306721, encodeId=987a1306e2124, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Feb 10 02:16:56 CST 2022, time=2022-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191167, encodeId=4249119116e31, content=很感兴趣的一个方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e831560211, createdName=ZYY7209, createdTime=Tue Feb 08 20:11:02 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191111, encodeId=7e7311911115b, content=内容祥实,, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89ae6481716, createdName=ms3000000637975859, createdTime=Tue Feb 08 18:35:09 CST 2022, time=2022-02-08, status=1, ipAttribution=)]
    2022-02-08 ZYY7209

    很感兴趣的一个方向

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1894838, encodeId=61db189483821, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Wed Mar 09 09:16:56 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022320, encodeId=6efd2022320b8, content=<a href='/topic/show?id=b4e43926560' target=_blank style='color:#2F92EE;'>#听力结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39265, encryptionId=b4e43926560, topicName=听力结果)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Sat Jan 07 20:16:56 CST 2023, time=2023-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306721, encodeId=987a1306e2124, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Feb 10 02:16:56 CST 2022, time=2022-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191167, encodeId=4249119116e31, content=很感兴趣的一个方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e831560211, createdName=ZYY7209, createdTime=Tue Feb 08 20:11:02 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191111, encodeId=7e7311911115b, content=内容祥实,, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89ae6481716, createdName=ms3000000637975859, createdTime=Tue Feb 08 18:35:09 CST 2022, time=2022-02-08, status=1, ipAttribution=)]
    2022-02-08 ms3000000637975859

    内容祥实,

    0

相关资讯

JAHA:绝对心血管疾病风险可预测老年人残疾和死亡率

绝对CVD风险与65岁以上人群的残疾和死亡率相关。即使在老年时进行评估,估计的CVD风险水平也可能是残疾和死亡风险的有用替代指标。

Eur J Heart Fail:左心房功能指标可预测低风险人群心衰

在一般人群中,LAVImin是发生HF的独立预测因子。LAVImax是目前常规超声心动图检查中唯一的LA测量指标,并非HF发生的独立预测指标。

JNER:神经系统疾病患者机器人神经康复步行功能预后的预测

神经系统疾病往往是慢性的、使人衰弱的,给家庭和社会带来沉重负担。改善活动能力是神经系统疾病患者康复的主要目标之一 。在神经康复中,高剂量和强度、足够的练习、个性化目标、动机和专业知识都是获得更好结果的

JAHA:基于血浆代谢物的心脏手术相关急性肾损伤预测

高分辨率代谢组学对于开发新的生物标志物来说效应足够强大。3种代谢物的血浆水平可用于早期识别CSA-AKI患者。

ARD:类风湿关节炎不同类型治疗成功的基线预测因子

RA治疗成功的预测是有限的。特别是在早期RA中,状态目标的预测可以通过较低的疾病活动基线水平来实现。性别和疾病持续时间可能会提高状态目标的可预测性。

Crit Care:危重患者拔管结局的预测

许多因素与通过自主呼吸试验的危重患者的拔管失败相关。稳健的多参数临床评分和/或人工智能算法应基于所选的自变量进行评估,以改进临床情景中对拔管结局的预测效能。