NEJM:真菌性眼内炎-病例报道

2020-05-07 MedSci原创 MedSci原创

手术后,患者右眼的视力提高到20/30,他接受伏立康唑口服治疗6周。在为期6个月的随访中,他的视力稳定,并且没有复发的迹象。

患者为一名34岁的男子,因右眼视力下降伴疼痛1周到眼科门诊就诊,曾有静脉用药和丙型肝炎病毒感染史。

检查时,右眼的视力为20/400,左眼的视力为20/20。右眼裂隙灯检查显示结膜注射和前房炎症。间接检眼镜检查显示玻璃体混浊,视网膜和视神经上有黄白色病变(如图A箭头所示)。左眼检查正常。血液培养结果为阴性,经胸超声心动图检查未见有赘生物。怀疑为真菌性眼内炎,并开始口服和玻璃体内注射伏立康唑治疗。

尽管进行了抗真菌治疗,玻璃体病变仍存在,因此,患者接受了玻璃体切除术。在手术过程中,发现粘附在视神经上的白色肿块(尺寸为4 mm x 3 mm x 1 mm)(如图B所示),并通过角膜侧面的切口去除(如图C显示的肿块)。对该肿块进行病理分析发现银染色(如图D箭头所示)有真菌酵母形式的坏死性肉芽肿,这一发现与念珠菌属感染一致。

手术后,患者右眼的视力提高到20/30,他接受伏立康唑口服治疗6周。在为期6个月的随访中,他的视力稳定,并且没有复发的迹象。

原始出处:

John R. Chancellor,et al.Fungal Endophthalmitis.N Engl J Med 2020;https://www.nejm.org/doi/full/10.1056/NEJMicm1911882?query=featured_secondary

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    2020-05-08 zhaojie88
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    2020-05-07 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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