这种茶或可逆转代谢紊乱!降低血糖水平还能改善肠道健康

2022-08-02 转化医学网 网络

绿茶有可能部分地在肠道水平起作用,减轻患代谢综合征的风险,而且对于已经患有代谢综合征的患者,甚至可以逆转它。

导读:流行病学显示,代谢综合征人群的发病率正以惊人的速度上升。代谢综合症会可造成多种疾病增加,如糖尿病、高血压、冠心病、脑卒中、甚至某些癌症。最近,有一项研究揭示了绿茶提取物对血糖和肠道健康的改善,为人们提供了一种新的以食物为基础的工具,以帮助管理他们患代谢综合征的风险或逆转代谢综合征。

一项针对具有一系列代谢紊乱风险因素的人群的新研究表明,连续四周食用绿茶提取物既能够降低血糖水平,还可以降低炎症和减少“肠漏”,以改善肠道健康。研究人员表示,这是第一项评估绿茶对于肠道的抗炎作用是否能降低与代谢综合征相关的健康风险的研究。研究结果发表在《Current Developments in Nutrition》杂志上。

https://academic.oup.com/cdn/article/6/Supplement_1/981/6606956?login=false

01代谢综合征现况

代谢综合征是指人体的蛋白质、脂肪、碳水化合物等物质发生代谢紊乱的病理状态,是一组复杂的代谢紊乱症候群,包括肥胖、高血糖、高血压、血脂异常、高血黏、高尿酸、高脂肪肝等特点。

代谢综合征会损害心脑肾等重要器官,是糖尿病的预发信号,接近一半的糖尿病患者是由代谢综合征发展而来的。它还是心脑血管疾病的预发信号,患有代谢综合征的人,未来更容易患中风、心梗等疾病。

此外,代谢综合征与恶性肿瘤也有密切的关系。由于代谢综合征是我们人体内的各种代谢紊乱而引起的,而这些就给肿瘤细胞提供了肥沃的土壤,使体内的恶性肿瘤细胞不断增加。大量研究显示,代谢综合征会不同程度的引发,或者加重肿瘤患者的病情。

2010-2012年中国居民营养与健康状况调查对98042名18岁及以上居民依据美国胆固醇教育计划成人治疗组第三次报告(NCEP-ATPⅢ)代谢综合征诊断标准,报告中国居民代谢综合征的标化患病率为24.2%。流行病学显示,发病率还在不断上升。因此,疾病的预防和改善极为重要。

02 “食疗”法改善

患有代谢综合征的人被诊断出至少具有增加心脏病、糖尿病和其他健康问题风险的五种因素中的三种——腹部脂肪过多、高血压、高密度脂蛋白(有益)胆固醇低、空腹血糖和甘油三酯(血液中的一种脂肪)水平高。Bruno说,这些构成代谢综合征的风险因素的棘手之处在于,它们通常只有轻微的改变,还不需要药物管理,但仍然对健康构成很大的风险。

“大多数医生最初会建议减肥和锻炼。但我们知道大多数人由于各种原因很难改变生活方式,”他说,“我们的工作旨在为人们提供一种新的以食物为基础的工具,以帮助管理他们患代谢综合征的风险或逆转代谢综合征。”

40名参与者(21名代谢综合征患者和19名健康成年人)连续28天食用含有丰富抗炎化合物儿茶素的绿茶提取物的软糖。每天的绿茶提取物的剂量相当于五杯绿茶。在随机双盲交叉试验中,所有参与者再服用安慰剂28天,而不服用任何补充剂。在服用安慰剂和绿茶提取物软糖阶段,参与者皆按照建议遵循了低多酚(水果、蔬菜、茶和香料中天然存在的抗氧化剂)饮食,所以任何实验结果都可以归结为绿茶造成的影响。

结果显示,与服用安慰剂相比,所有参与者在服用绿茶提取物后的空腹血糖水平显著降低。此外,分析表明,不论是患有代谢综合征的人还是健康人,在进行绿茶“治疗”后,其粪便样本中的促炎蛋白减少,表明参与者的肠道炎症因绿茶“治疗”而减少。不仅如此,通过一项评估尿液样本中糖比例的技术,研究人员还发现,饮用绿茶后,参与者的小肠通透性明显下降。

肠道通透性,也称肠漏,会使肠道细菌和相关有毒化合物进入血液,刺激低级别慢性炎症。Bruno说:“对肠道衍生产品的吸收被认为是肥胖和胰岛素抵抗的起始因素,这是所有心脏代谢紊乱的核心。如果我们能够改善肠道完整性,减少肠道漏液,就不仅能够缓解引发心脏代谢紊乱的低级别炎症,还可能逆转它们。”

“我们并没有试图用一个月的研究来治愈代谢综合征。但根据我们对代谢综合征背后的因果因素的了解,绿茶有可能部分地在肠道水平起作用,减轻患代谢综合征的风险,而且对于已经患有代谢综合征的患者,甚至可以逆转它。”

目前,Bruno的实验室正在完成对研究参与者肠道中的微生物群落和血液中与细菌相关的毒素水平的进一步分析。

参考资料:

https://medicalxpress.com/news/2022-07-green-tea-gut-health-lowers.html

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    2022-08-04 ms6000000130686318

    学习了

    0

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    2022-08-04 hbwxf
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    2022-08-03 ColinGao

    这种事情李大佬的小学生女儿都知道的

    0

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    2022-08-02 ms3000001183602181

    学习了

    0

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