NEJM:Satralizumab治疗视神经脊髓炎谱系疾病的SAkuraSky III期研究取得喜人结果

2019-11-30 Allan MedSci原创

日本中外制药株式会社宣布,有关satralizumab的全球III期SAkuraSky研究(NCT02028884)的结果已于11月27日在NEJM在线发表。Satralizumab是一种抗IL6受体抗体,正在开发用于治疗视神经脊髓炎谱系疾病(NMOSD)。

日本中外制药株式会社宣布,有关satralizumab的全球IIISAkuraSky研究(NCT02028884)的结果已于1127日在NEJM在线发表。Satralizumab是一种抗IL6受体抗体,正在开发用于治疗视神经脊髓炎谱系疾病(NMOSD)。 

视神经脊髓炎谱系疾病(NMOSD)过去称为Devic病或视神经脊髓炎(NMO),是中枢神经系统炎性疾病,特征为免疫介导的严重脱髓鞘及轴突损伤,主要累及视神经和脊髓。中外公司执行副总裁Yasushi Ito博士说:“ NMOSD的复发可能导致残疾的积累,并可能危及生命。这些数据进一步强调了IL-6信号抑制在治疗NMOSD中的重要性


原始出处:

http://www.firstwordpharma.com/node/1684295?tsid=4#axzz66lVeGfcw

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level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri May 01 16:18:00 CST 2020, time=2020-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657261, encodeId=5004165e26160, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sun Feb 23 10:18:00 CST 2020, time=2020-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916197, encodeId=525c191619e27, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Feb 08 19:18:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1666996, encodeId=79be16669967e, content=<a href='/topic/show?id=5fda90e061e' target=_blank style='color:#2F92EE;'>#视神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90706, encryptionId=5fda90e061e, topicName=视神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14db26078051, createdName=gj0740, createdTime=Fri Jan 24 20:18:00 CST 2020, time=2020-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650452, encodeId=245e165045252, content=<a href='/topic/show?id=b14384624a3' target=_blank style='color:#2F92EE;'>#脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84624, encryptionId=b14384624a3, topicName=脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06db24008155, createdName=xlysu, createdTime=Tue May 26 00:18:00 CST 2020, time=2020-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947491, encodeId=f2ca194e4919f, content=<a href='/topic/show?id=c11f29e67e' target=_blank style='color:#2F92EE;'>#ATRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2976, encryptionId=c11f29e67e, topicName=ATRA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Sat Mar 14 21:18:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949508, encodeId=e379194950851, content=<a href='/topic/show?id=f237e452185' target=_blank style='color:#2F92EE;'>#神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74521, encryptionId=f237e452185, topicName=神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue May 05 10:18:00 CST 2020, time=2020-05-05, status=1, ipAttribution=)]
    2020-05-01 snf701207
  5. [GetPortalCommentsPageByObjectIdResponse(id=1202409, encodeId=26631202409ad, content=<a href='/topic/show?id=e30d90e23cf' target=_blank style='color:#2F92EE;'>#视神经脊髓炎谱系疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90723, encryptionId=e30d90e23cf, topicName=视神经脊髓炎谱系疾病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Mon Mar 14 10:29:03 CST 2022, time=2022-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021356, encodeId=af84202135643, content=<a href='/topic/show?id=69d595e421' target=_blank style='color:#2F92EE;'>#III期研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9574, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650452, encodeId=245e165045252, content=<a href='/topic/show?id=b14384624a3' target=_blank style='color:#2F92EE;'>#脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84624, encryptionId=b14384624a3, topicName=脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06db24008155, createdName=xlysu, createdTime=Tue May 26 00:18:00 CST 2020, time=2020-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947491, encodeId=f2ca194e4919f, content=<a href='/topic/show?id=c11f29e67e' target=_blank style='color:#2F92EE;'>#ATRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2976, encryptionId=c11f29e67e, topicName=ATRA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Sat Mar 14 21:18:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949508, encodeId=e379194950851, content=<a href='/topic/show?id=f237e452185' target=_blank style='color:#2F92EE;'>#神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74521, encryptionId=f237e452185, topicName=神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue May 05 10:18:00 CST 2020, time=2020-05-05, status=1, ipAttribution=)]
    2020-02-23 bsmagic9140
  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650452, encodeId=245e165045252, content=<a href='/topic/show?id=b14384624a3' target=_blank style='color:#2F92EE;'>#脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84624, encryptionId=b14384624a3, topicName=脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06db24008155, createdName=xlysu, createdTime=Tue May 26 00:18:00 CST 2020, time=2020-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947491, encodeId=f2ca194e4919f, content=<a href='/topic/show?id=c11f29e67e' target=_blank style='color:#2F92EE;'>#ATRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2976, encryptionId=c11f29e67e, topicName=ATRA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Sat Mar 14 21:18:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949508, encodeId=e379194950851, content=<a href='/topic/show?id=f237e452185' target=_blank style='color:#2F92EE;'>#神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74521, encryptionId=f237e452185, topicName=神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue May 05 10:18:00 CST 2020, time=2020-05-05, status=1, ipAttribution=)]
    2020-02-08 docwu2019
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650452, encodeId=245e165045252, content=<a href='/topic/show?id=b14384624a3' target=_blank style='color:#2F92EE;'>#脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84624, encryptionId=b14384624a3, topicName=脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06db24008155, createdName=xlysu, createdTime=Tue May 26 00:18:00 CST 2020, time=2020-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947491, encodeId=f2ca194e4919f, content=<a href='/topic/show?id=c11f29e67e' target=_blank style='color:#2F92EE;'>#ATRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2976, encryptionId=c11f29e67e, topicName=ATRA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Sat Mar 14 21:18:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949508, encodeId=e379194950851, content=<a href='/topic/show?id=f237e452185' target=_blank style='color:#2F92EE;'>#神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74521, encryptionId=f237e452185, topicName=神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue May 05 10:18:00 CST 2020, time=2020-05-05, status=1, ipAttribution=)]
    2020-01-24 gj0740
  8. [GetPortalCommentsPageByObjectIdResponse(id=1202409, encodeId=26631202409ad, content=<a href='/topic/show?id=e30d90e23cf' target=_blank style='color:#2F92EE;'>#视神经脊髓炎谱系疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90723, encryptionId=e30d90e23cf, topicName=视神经脊髓炎谱系疾病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Mon Mar 14 10:29:03 CST 2022, time=2022-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021356, encodeId=af84202135643, content=<a href='/topic/show?id=69d595e421' target=_blank style='color:#2F92EE;'>#III期研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9574, 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/XhttJCp4Aq9gKA5n4v9elclQlVQTDenMiaEiadlI5D3gtmfSiaicoIY4ZsuibrQKLibDdxBKVY8oS6B2FicqJlT93clow/132, createdBy=03202500144, createdName=ms7258648636991762, createdTime=Sat Mar 14 21:18:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949508, encodeId=e379194950851, content=<a href='/topic/show?id=f237e452185' target=_blank style='color:#2F92EE;'>#神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74521, encryptionId=f237e452185, topicName=神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Tue May 05 10:18:00 CST 2020, time=2020-05-05, status=1, ipAttribution=)]
    2020-05-26 xlysu
  9. 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  10. 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