J Agric Food Chem:长期摄入二氧化钛纳米颗粒对肠道炎症的影响

2020-05-08 MedSci原创 MedSci原创

早期摄取食物中的物质,如增白剂二氧化钛纳米粒子(TiO2 NPs),可导致成年后的长期影响。我们的目的是探讨长期饮食摄入TiO2 NPs可能产生的不良影响。

早期摄取食物中的物质,如增白剂二氧化钛纳米粒子(TiO2 NPs),可导致成年后的长期影响。我们的目的是探讨长期饮食摄入TiO2 NPs可能产生的不良影响。

 

从断奶后喂养2-3个月后,暴露于TiO2 NPs的小鼠表现出较低的体重和诱发肠道炎症。然而,这种现象在肠道微生物群移除的小鼠中没有观察到。TiO2 NPs暴露很少影响微生物群落的多样性,但显著降低了包括双歧杆菌和乳酸菌在内的几种益生菌分类群的丰度。此外,TiO2 NPs会加重DSS诱导的慢性结肠炎和体内免疫反应,并减少肠系膜淋巴结中CD4+T细胞、调节性T细胞和巨噬细胞的数量。

 

因此,膳食中的TiO2 NPs可能会干扰免疫系统的平衡和肠道微生物群的动态,从而导致低度肠道炎症,加重对外界刺激的免疫反应,从而带来潜在的健康风险。

 

原始出处:

 

Wei Mu, Yong Wang, et al., Effect of Long-Term Intake of Dietary Titanium Dioxide Nanoparticles on Intestine Inflammation in Mice. J Agric Food Chem. 2019 Aug 21;67(33):9382-9389. doi: 10.1021/acs.jafc.9b02391. Epub 2019 Aug 7.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1715595, encodeId=5b021e1559599, content=<a href='/topic/show?id=a217e58972' target=_blank style='color:#2F92EE;'>#food#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7589, encryptionId=a217e58972, topicName=food)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68d031960225, createdName=ms6747015003810650, createdTime=Mon Jan 11 02:41:38 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815122, encodeId=32ae181512202, content=<a href='/topic/show?id=a4679e00937' target=_blank style='color:#2F92EE;'>#长期摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97009, encryptionId=a4679e00937, topicName=长期摄入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sat Jun 13 18:41:38 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679839, encodeId=e03f16e98398a, content=<a href='/topic/show?id=d4ac9639efa' target=_blank style='color:#2F92EE;'>#钛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96397, encryptionId=d4ac9639efa, topicName=钛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=927227807332, createdName=30397613, createdTime=Wed Mar 17 21:41:38 CST 2021, time=2021-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323412, encodeId=a14d1323412f3, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sun May 10 07:41:38 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414772, encodeId=fdb31414e72a1, content=<a href='/topic/show?id=af1a8169e60' target=_blank style='color:#2F92EE;'>#肠道炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81697, encryptionId=af1a8169e60, topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Sun May 10 07:41:38 CST 2020, time=2020-05-10, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1715595, encodeId=5b021e1559599, content=<a href='/topic/show?id=a217e58972' target=_blank style='color:#2F92EE;'>#food#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7589, encryptionId=a217e58972, topicName=food)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68d031960225, createdName=ms6747015003810650, createdTime=Mon Jan 11 02:41:38 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815122, encodeId=32ae181512202, content=<a href='/topic/show?id=a4679e00937' target=_blank style='color:#2F92EE;'>#长期摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97009, encryptionId=a4679e00937, topicName=长期摄入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sat Jun 13 18:41:38 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679839, encodeId=e03f16e98398a, content=<a href='/topic/show?id=d4ac9639efa' target=_blank style='color:#2F92EE;'>#钛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96397, encryptionId=d4ac9639efa, topicName=钛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=927227807332, createdName=30397613, createdTime=Wed Mar 17 21:41:38 CST 2021, time=2021-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323412, encodeId=a14d1323412f3, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sun May 10 07:41:38 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414772, encodeId=fdb31414e72a1, content=<a href='/topic/show?id=af1a8169e60' target=_blank style='color:#2F92EE;'>#肠道炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81697, encryptionId=af1a8169e60, topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Sun May 10 07:41:38 CST 2020, time=2020-05-10, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1715595, encodeId=5b021e1559599, content=<a href='/topic/show?id=a217e58972' target=_blank style='color:#2F92EE;'>#food#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7589, encryptionId=a217e58972, topicName=food)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68d031960225, createdName=ms6747015003810650, createdTime=Mon Jan 11 02:41:38 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815122, encodeId=32ae181512202, content=<a href='/topic/show?id=a4679e00937' target=_blank style='color:#2F92EE;'>#长期摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97009, encryptionId=a4679e00937, topicName=长期摄入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sat Jun 13 18:41:38 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679839, encodeId=e03f16e98398a, content=<a href='/topic/show?id=d4ac9639efa' target=_blank style='color:#2F92EE;'>#钛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96397, encryptionId=d4ac9639efa, topicName=钛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=927227807332, createdName=30397613, createdTime=Wed Mar 17 21:41:38 CST 2021, time=2021-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323412, encodeId=a14d1323412f3, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sun May 10 07:41:38 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414772, encodeId=fdb31414e72a1, content=<a href='/topic/show?id=af1a8169e60' target=_blank style='color:#2F92EE;'>#肠道炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81697, encryptionId=af1a8169e60, topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Sun May 10 07:41:38 CST 2020, time=2020-05-10, status=1, ipAttribution=)]
    2021-03-17 30397613
  4. [GetPortalCommentsPageByObjectIdResponse(id=1715595, encodeId=5b021e1559599, content=<a href='/topic/show?id=a217e58972' target=_blank style='color:#2F92EE;'>#food#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7589, encryptionId=a217e58972, topicName=food)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68d031960225, createdName=ms6747015003810650, createdTime=Mon Jan 11 02:41:38 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815122, encodeId=32ae181512202, content=<a href='/topic/show?id=a4679e00937' target=_blank style='color:#2F92EE;'>#长期摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97009, encryptionId=a4679e00937, topicName=长期摄入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sat Jun 13 18:41:38 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679839, encodeId=e03f16e98398a, content=<a href='/topic/show?id=d4ac9639efa' target=_blank style='color:#2F92EE;'>#钛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96397, encryptionId=d4ac9639efa, topicName=钛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=927227807332, createdName=30397613, createdTime=Wed Mar 17 21:41:38 CST 2021, time=2021-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323412, encodeId=a14d1323412f3, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sun May 10 07:41:38 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414772, encodeId=fdb31414e72a1, content=<a href='/topic/show?id=af1a8169e60' target=_blank style='color:#2F92EE;'>#肠道炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81697, encryptionId=af1a8169e60, topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Sun May 10 07:41:38 CST 2020, time=2020-05-10, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1715595, encodeId=5b021e1559599, content=<a href='/topic/show?id=a217e58972' target=_blank style='color:#2F92EE;'>#food#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7589, encryptionId=a217e58972, topicName=food)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68d031960225, createdName=ms6747015003810650, createdTime=Mon Jan 11 02:41:38 CST 2021, time=2021-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815122, encodeId=32ae181512202, content=<a href='/topic/show?id=a4679e00937' target=_blank style='color:#2F92EE;'>#长期摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97009, encryptionId=a4679e00937, topicName=长期摄入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Sat Jun 13 18:41:38 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679839, encodeId=e03f16e98398a, content=<a href='/topic/show?id=d4ac9639efa' target=_blank style='color:#2F92EE;'>#钛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96397, encryptionId=d4ac9639efa, topicName=钛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=927227807332, createdName=30397613, createdTime=Wed Mar 17 21:41:38 CST 2021, time=2021-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323412, encodeId=a14d1323412f3, content=<a href='/topic/show?id=d8d5e7476de' target=_blank style='color:#2F92EE;'>#纳米颗粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77476, encryptionId=d8d5e7476de, topicName=纳米颗粒)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Sun May 10 07:41:38 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414772, encodeId=fdb31414e72a1, content=<a href='/topic/show?id=af1a8169e60' target=_blank style='color:#2F92EE;'>#肠道炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81697, encryptionId=af1a8169e60, topicName=肠道炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1f3086480, createdName=lancelotzzl, createdTime=Sun May 10 07:41:38 CST 2020, time=2020-05-10, status=1, ipAttribution=)]

相关资讯

J Periodon Res:lncRNA MALAT1通过sponging miR-20a和激活TLR4通路调节脂多糖刺激的人牙龈成纤维细胞炎症细胞因子的产生

长非编码RNA(lnc RNAs),如肺腺癌转移相关转录因子 1 (MALAT1),是炎症性疾病发展的关键调节因子。 然而,目前尚不清楚MALAT1是否调节人牙龈成纤维细胞(HGFs)在牙周炎中的作用

2020 专家共识:FDG PET/CT在感染和炎症中的应用

为了进一步促进 18F-FDG PET-CT在感染和炎症中的临床应用,规范诊断流程,中国有关领域内的专家对上述内容进行讨论,形成了专家共识。

Nature:科学家发现触发细胞死亡和炎症的新机制:“左手杀手”

最新研究背后的一个关键问题是在没有病毒感染的情况下如何激活ZBP1。

JCC:炎症性肠病患者的口服铁吸收能力与肠道炎症有关而非病变部位

贫血在炎症性肠病[IBD]中很常见,其两个主要病因是缺铁性贫血[IDA]和慢性炎症性贫血[ACI]。炎症细胞因子引起的肠铁吸收受损被认为在ACI中起主要作用,

Circulation:Regnase-1通过介导细胞因子mRNA降解抑制衰竭心脏的无菌性炎症

促炎细胞因子在心力衰竭的发病机制中起着重要作用。衰竭心脏内维持无菌性炎症的机制仍不明确。虽然转录调控对促炎细胞因子基因表达很重要,但mRNA的稳定性也有助于免疫反应的动态。Regnase-1是一种RNase,参与免疫细胞中一系列促炎细胞因子mRNA的降解。但Regnase-1在非免疫细胞(如心肌细胞)中的作用仍有待阐明。为了研究Regnase-1在心肌细胞中介导促炎细胞因子降解的作用,研究人员建立

J Periodontal Res:Netrin-1及其受体Unc5b作为牙周病标记物

Netrin-1通过其受体UNC5b调节炎症反应,并在骨破坏性疾病中发挥作用。本研究的目的是评估Netrin-1和Unc5b在牙周健康和疾病中的水平。