Hepatology:慢性丙型肝炎增加慢性肾脏病的风险!

2017-09-10 MedSci MedSci原创

近期,一项发表在杂志Hepatology上的研究旨在评估慢性丙型肝炎病毒(HCV)感染患者发生慢性肾脏疾病(CKD)的风险,以及接受HCV治疗后CKD发生率的降低情况。此外,还评估了慢性HCV患者膜增生性肾小球肾炎(MPGN)和冷球蛋白血症的风险。研究者们对美国Truven Health MarketScan数据库(2008-2015)进行了回顾性队列分析。在56,448例HCV感染患者和倾向评分

近期,一项发表在杂志Hepatology上的研究旨在评估慢性丙型肝炎病毒(HCV)感染患者发生慢性肾脏疾病(CKD)的风险,以及接受HCV治疗后CKD发生率的降低情况。此外,还评估了慢性HCV患者膜增生性肾小球肾炎(MPGN)和冷球蛋白血症的风险。研究者们对美国Truven Health MarketScan数据库(2008-2015)进行了回顾性队列分析。在56,448例HCV感染患者和倾向评分(1:3)的队列中匹配了169,344例非HCV患者,随后检测了HCV感染与CKD发生率的关系。 此项研究结果显示:在55,818例HCV患者中,分别有6.6%(n = 3666),6.3%(n = 3534)和8.3%(n = 4628)患者接受基于干扰素的双重,三联或全口服的直接作用的抗病毒药物(DAA)治疗,而79%的患者没有接受任何针对HCV的治疗。使用Cox比例风险模型分析比较了HCV患者与非HCV患者以及未治疗HCV患者和治疗患者发生CKD的风险。在多变量时变Cox回归模型中,与非HCV患者相比,HCV感染患者的CKD风险增加了27%(危险比(HR),1.27;95%置信

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    2017-09-12 gwc384
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    2017-09-11 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2017-09-10 tanxingdoctor

    学习啦!谢谢分享!

    0

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    2017-09-10 清风拂面

    谢谢分享.学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1647897, encodeId=7ecb164e89756, content=<a href='/topic/show?id=ac125345160' target=_blank style='color:#2F92EE;'>#慢性丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53451, encryptionId=ac125345160, topicName=慢性丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d24523536533, createdName=zjubiostat, createdTime=Mon Jul 16 02:22:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274599, encodeId=4d0c12e459965, content=<a href='/topic/show?id=30872089e03' target=_blank style='color:#2F92EE;'>#丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20897, encryptionId=30872089e03, topicName=丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Tue Sep 12 03:22:00 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426833, encodeId=d2681426833c0, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Tue Sep 12 03:22:00 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616124, encodeId=7cfe16161248b, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Tue Sep 12 03:22:00 CST 2017, time=2017-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242967, encodeId=12c024296e46, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Sep 11 21:56:25 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242612, encodeId=dd8924261215, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Sep 10 20:33:39 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242581, encodeId=766c24258106, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Sep 10 18:33:22 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242540, encodeId=f5332425409b, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Sep 10 13:42:52 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242533, encodeId=97c924253380, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sun Sep 10 12:47:08 CST 2017, time=2017-09-10, status=1, ipAttribution=)]
    2017-09-10 131****1460

    学习了受益匪浅

    0

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    2017-09-10 榄枷檬

    谢谢分享

    0

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