Heart:特纳综合征女性妊娠的心血管结局

2020-07-19 MedSci原创 MedSci原创

这项研究有助于完善TS妇女的妊娠途径,在没有结构性心脏病的TS妇女中,妊娠不会增加CV结局的风险。在伴有结构性心脏病的TS妇女中,妊娠风险并不像先前描述的那样令人难以置信,但确实需要进行持续评估。

由于缺乏数据和主动脉夹层风险不清楚,特纳综合征(TS)女性经常被建议避免怀孕。但是,随着生育疗法的进步,越来越多的TS妇女正在考虑妊娠。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,这项研究旨在比较了(1)患有TS的孕妇和非孕妇,以及(2)伴有/不伴有结构性心脏病的TS孕妇的不良血管(CV)结局发生率。

研究人员回顾性分析了10个CV中心的妊娠和年龄匹配的非妊娠TS患者(2005-2017)。在妊娠初期评估时收集数据,并评估产后6个月的结局。不良心血管事件定义为心血管死亡、主动脉夹层/破裂和/或主动脉干预。在同一时间段随访未怀孕的年龄匹配对照者。

该研究包括68例妊娠(60名妇女,平均年龄为33岁,初次妊娠48%,生育疗法49%,心脏结构正常80%,XO核型25%)。根据美国生殖医学学会的标准,10名孕妇发生了分层为高风险类别的妊娠。TS孕妇或未怀孕的妇女均未发生CV事件。12次(18%)妊娠并发产科事件,其中9次(13%)归因于妊娠高血压疾病。胎儿事件包括胎龄较小的婴儿(18%)、早产(15%)和胎儿死亡(3%)。

这项研究有助于完善TS妇女的妊娠途径,在没有结构性心脏病的TS妇女中,妊娠不会增加CV结局的风险。在伴有结构性心脏病的TS妇女中,妊娠风险并不像先前描述的那样令人难以置信,但确实需要进行持续评估。

原始出处:

Jasmine Grewal.et al.Cardiovascular outcomes of pregnancy in Turner syndrome.heart.2020.http://dx.doi.org/10.1136/heartjnl-2020-316719

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    2020-08-07 咻凡

    这个杂志好头吗

    0

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    2020-07-21 zhaojie88
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    2020-07-21 slcumt
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    2020-07-20 1240394fm61暂无昵称

    不根据心功能评估是否可以妊娠吗?

    0

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