Sci Rep:佩罗尼氏病患者胶原酶梭状芽孢杆菌治疗失败后的手术结果多中心临床研究

2021-01-30 AlexYang MedSci原创

最近,有研究人员调查了胶原酶梭状芽孢杆菌(CCH)斑块内注射后持续阴茎弯曲(PC)患者的手术效果。

最近,有研究人员调查了胶原酶梭状芽孢杆菌(CCH)斑块内注射后持续阴茎弯曲(PC)患者的手术效果

研究人员回顾性地审查了来自6个泌尿外科中心的90名CCH后持续性PC患者的数据。研究人员进行了三种标准化的外科手术。第1组:斑块切口移植(PIG)与阴茎假体植入(PPI);第2组。PIG但无PPI;第3组:Nesbit技术。评估了住院时间、手术时间、术后并发症和PC持续性/复发(>20°)情况;并在术前和术后3个月中,通过国际勃起功能指数-勃起功能(IIEF-EF)、佩罗尼氏病问卷(PDQ)、女性性功能指数(FSFI)评估了总体满意度和功能结果。其中,25名(27.8%)患者接受了移植手术+PPI(第1组),18名(20.0%)患者为第2组,47名(52.2%)为第3组,牛心包移植物和胶原绒分别用于22名(51.2%)和21名(48.8%)患者。结果表明,术后阴茎长度中位数为13.0cm(IQR 12.0-15.0)。术后,第1组阴茎长度增加较多,PDQ-PS方面改善较好。IIEF-EF和FSFI评分在各组间均无差异。总的来说,86名(95.6%)患者没有报告任何并发症。4名(4.4%)患者出现PC复发;其中,第1组、第2组和第3组分别有2名(8.0%)、1名(5.6%)和1名(2.1%)。

三组中从基线到随访终止时的临床变量变化均值

最后,研究人员指出,对于CCH后的持续性PC,采用移植手术矫正,并使用或不使用PPI或Nesbit技术,可成为技术上可行、有效和安全的手术,且术后无明显并发症

原始出处:

Andrea Cocci, David Ralph, Rados Djinovic et al. Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie's disease in a multicenter clinical study. Sci Rep. Jan 2021

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