Stroke:胰岛素样肽-1受体激动剂可降低T2D患者非致命性卒中的发病风险

2020-08-20 MedSci原创 MedSci原创

本研究旨在对CVOTs(心血管结果试验)进行荟萃分析,以评估糖皮质激素样肽-1受体激动剂治疗对降低2型糖尿病患者卒中风险的效果。

本研究旨在对CVOTs(血管结果试验)进行荟萃分析,以评估糖皮质激素样肽-1受体激动剂治疗对降低2型糖尿病患者卒中风险的效果。

研究人员搜索了PubMed和其他电子来源2019年6月20日以前收录的相关研究。在汇集各试验数据后,使用具有95%CIs的危害比作为衡量使用糖皮质激素样肽-1受体激动剂与卒中风险之间的关联。

 

结果,研究共确认7个CVOTs,56004名参与者。2型糖尿病患者使用糖肽样肽-1受体激动剂与非致命性卒中风险降低15%(P=0.002)、致命性卒中风险降低19%(P=0.150)、总卒中风险降低16%(P=0.001)相关。血红蛋白A1c水平或体重的降低与卒中风险之间没有关联。

综上所述,该研究结果表明,胰岛素样肽-1受体激动剂可降低T2D患者非致命性卒中的发病风险。

 

原始出处:

 

Giuseppe BellastellaMaria Ida Maiorino, et al., Glucagon-Like Peptide-1 Receptor Agonists and Prevention of Stroke Systematic Review of Cardiovascular Outcome Trials With Meta-Analysis. Stroke. 2020 Feb;51(2):666-669. doi: 10.1161/STROKEAHA.119.027557. 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1750172, encodeId=971e1e50172ad, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Mar 08 23:42:46 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809826, encodeId=691e180982612, content=<a href='/topic/show?id=04878388e33' target=_blank style='color:#2F92EE;'>#胰岛素样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83887, encryptionId=04878388e33, topicName=胰岛素样)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 09 16:42:46 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627832, encodeId=8da7162e8323a, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Sat Aug 22 09:42:46 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026685, encodeId=6611102668590, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Aug 20 21:42:46 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811570, encodeId=4c518115e0d5, content=胰岛素样肽-1受体激动剂可降低T2D患者非致命性卒中的发病风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Thu Aug 20 20:26:46 CST 2020, time=2020-08-20, status=1, ipAttribution=)]
    2021-03-08 baoya
  2. [GetPortalCommentsPageByObjectIdResponse(id=1750172, encodeId=971e1e50172ad, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Mar 08 23:42:46 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809826, encodeId=691e180982612, content=<a href='/topic/show?id=04878388e33' target=_blank style='color:#2F92EE;'>#胰岛素样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83887, encryptionId=04878388e33, topicName=胰岛素样)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 09 16:42:46 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627832, encodeId=8da7162e8323a, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Sat Aug 22 09:42:46 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026685, encodeId=6611102668590, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Aug 20 21:42:46 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811570, encodeId=4c518115e0d5, content=胰岛素样肽-1受体激动剂可降低T2D患者非致命性卒中的发病风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Thu Aug 20 20:26:46 CST 2020, time=2020-08-20, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1750172, encodeId=971e1e50172ad, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Mar 08 23:42:46 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809826, encodeId=691e180982612, content=<a href='/topic/show?id=04878388e33' target=_blank style='color:#2F92EE;'>#胰岛素样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83887, encryptionId=04878388e33, topicName=胰岛素样)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 09 16:42:46 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627832, encodeId=8da7162e8323a, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Sat Aug 22 09:42:46 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026685, encodeId=6611102668590, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Aug 20 21:42:46 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811570, encodeId=4c518115e0d5, content=胰岛素样肽-1受体激动剂可降低T2D患者非致命性卒中的发病风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Thu Aug 20 20:26:46 CST 2020, time=2020-08-20, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1750172, encodeId=971e1e50172ad, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Mar 08 23:42:46 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809826, encodeId=691e180982612, content=<a href='/topic/show?id=04878388e33' target=_blank style='color:#2F92EE;'>#胰岛素样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83887, encryptionId=04878388e33, topicName=胰岛素样)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 09 16:42:46 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627832, encodeId=8da7162e8323a, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Sat Aug 22 09:42:46 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026685, encodeId=6611102668590, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Aug 20 21:42:46 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811570, encodeId=4c518115e0d5, content=胰岛素样肽-1受体激动剂可降低T2D患者非致命性卒中的发病风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Thu Aug 20 20:26:46 CST 2020, time=2020-08-20, status=1, ipAttribution=)]
    2020-08-20 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1750172, encodeId=971e1e50172ad, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Mar 08 23:42:46 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809826, encodeId=691e180982612, content=<a href='/topic/show?id=04878388e33' target=_blank style='color:#2F92EE;'>#胰岛素样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83887, encryptionId=04878388e33, topicName=胰岛素样)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 09 16:42:46 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627832, encodeId=8da7162e8323a, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Sat Aug 22 09:42:46 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026685, encodeId=6611102668590, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Aug 20 21:42:46 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=811570, encodeId=4c518115e0d5, content=胰岛素样肽-1受体激动剂可降低T2D患者非致命性卒中的发病风险, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Thu Aug 20 20:26:46 CST 2020, time=2020-08-20, status=1, ipAttribution=)]
    2020-08-20 神盾医疗局局长Jack

    胰岛素样肽-1受体激动剂可降低T2D患者非致命性卒中的发病风险

    0

相关资讯

Circulation:冠脉搭桥术中结扎左心耳对房颤患者短期预后的影响

心房颤动导致的卒中,90%以上的血栓起源于左心耳,封堵左心耳是否可减少房颤患者的卒中率?

Stroke:西洛他唑用于卒中和认知功能下降的二级预防

西洛他唑可以有效长期预防复发性卒中,而不会增加出血的风险。但是,大多数与亚太地区患者有关的试验以及西方国家的更多试验应评估其对认知功能下降、功能结局和耐受性的影响。

类似于急性冠脉综合征及中风,你会想起该病吗?

嗜酸性肉芽肿性多血管炎,也称为Churg-Strauss综合征(churg-strauss syndrome,CSS),以哮喘、嗜酸性粒细胞增多及血管炎为临床表现的、累及多器官的罕见疾病。

J Cereb Blood Flow Metab:卒中诱导的免疫抑制和吞咽困难与卒中相关肺炎独立相关

脑卒中相关肺炎是脑卒中后常见的并发症,与不良结局有关。吞咽困难是脑卒中相关肺炎的已知危险因素,但现有的证据表明,脑卒中诱导的免疫抑制状态增加了脑卒中相关肺炎的易感性。本研究旨在通过研究单细胞HLA-D

Neurology:服用达比加群卒中患者的溶栓治疗

达比加群酯(达比加群)是一种直接凝血酶抑制剂,已被证明可预防心房颤动患者的卒中。伊达鲁珠单抗(Idarucizumab)是一种人源化单克隆抗体片段,旨在逆转达比加群的抗凝作用。伊达鲁珠单抗与达比加群的

进口干细胞治疗卒中的临床试验在北京天坛医院启动

2020年7月6日,九芝堂美科与北京天坛医院正式签署临床试验合作协议,标志着中国首个进口干细胞新药临床试验即将启动,适应症为“缺血性卒中”。