Brit J Cancer:中性粒细胞与淋巴细胞比值对肝细胞癌患者预后和诊断的意义

2021-06-14 MedSci原创 MedSci原创

中性粒细胞-淋巴细胞比率(NLR)是衡量中性粒细胞相关的肿瘤前炎症和淋巴细胞依赖的抗肿瘤免疫功能之间平衡的一种假定指标,NLR是影响HCC患者生存的一个重要的独立因素。

中性粒细胞-淋巴细胞比率(NLR)是衡量中性粒细胞相关的肿瘤前炎症和淋巴细胞依赖的抗肿瘤免疫功能之间平衡的一种假定指标,已被认为是包括肝细胞癌(HCC)在内的几种癌症的预后指标。

近日,肿瘤学领域权威杂志British Journal of Cancer上发表了一篇研究文章,在这项研究中,研究人员对包括781例患者(493例肝细胞癌和288例无肝细胞癌的慢性肝病)的前瞻性累积队列进行了超过6年的随访。

研究人员比较了肝癌和慢性肝病患者之间的NLR水平,并通过多变量Cox回归分析评估基线NLR对肝癌患者总生存期的影响。

生存曲线

在研究开始时(基线),慢性肝病患者和HCC患者的NLR值没有临床显著性差异。在HCC患者中,与上次就诊/死亡最接近的NLR水平显著高于基线水平。多变量Cox回归分析显示NLR是一个独立的预后指标,即使对HCC分期进行了调整。

由此可见,NLR是影响HCC患者生存的一个重要的独立因素

原始出处:

Philip J. Johnson.et al.The prognostic and diagnostic significance of the neutrophil-to-lymphocyte ratio in hepatocellular carcinoma: a prospective controlled study.Brit J Cancer.2021.https://www.nature.com/articles/s41416-021-01445-3

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    2021-08-25 xjy02
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    2021-06-15 1475527am93暂无昵称

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    2021-06-15 2289576799

    中性粒细胞比例

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    2021-06-15 ms9000000276557869

    好人一生平安

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