Circulation:减肥和心力衰竭—胃旁路手术与强化改变生活方式对比

2017-04-25 xiangting MedSci原创

这项针对2个全国性登记中心的研究显示胃旁路手术后肥胖心衰发生率大约相当于强化生活方式改变的一半。

此前已经观察到肥胖和心力衰竭的关联,但因果关系还不明确。研究人员提出假设:在肥胖人群中胃旁路手术比改变生活方式后的心衰发生率低。

研究对象包括来自瑞典全国注册中心的无心衰接受改变生活方式计划的肥胖人群和斯堪的纳维亚肥胖手术登记处。所有分析使用基于体重指数的反概率权重和基线变量估计的倾向评分。组间在体重、体重指数和大多数潜在混杂因素方面均衡。按照国家患者登记册的定义,使用Cox回归计算治疗方式和心衰发生率的相关性。

25 804例胃旁路手术患者比13 701例改变生活方式的患者在1年后平均多减重18.8 kg,2年后多减重22.6 kg以上。在中位数4.1年中,手术患者的心衰发生率低于改变生活方式患者(风险比为0.54; 95%置信区间,0.36-0.82)。两组中1年后实现体重减轻10公斤与心衰相关的风险比为0.77(95%置信区间,0.60-0.97)。结果在敏感性分析中是稳健的。

这项针对2个全国性登记中心的研究显示胃旁路手术后肥胖心衰发生率大约相当于强化生活方式改变的一半。此外还观察到减重增多和心衰风险降低之间的分级关联。

原始出处:


本文系梅斯医学(MedSci)原创编译整理,转载需授权

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1934230, encodeId=3caf193423031, content=<a href='/topic/show?id=72108319e63' target=_blank style='color:#2F92EE;'>#胃旁路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83197, encryptionId=72108319e63, topicName=胃旁路)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Sat Mar 31 23:19:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194893, encodeId=9c8d19489351, content=文章很好,值得读, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun May 07 08:16:52 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587002, encodeId=3e5b158e00252, content=<a href='/topic/show?id=a4be8319879' target=_blank style='color:#2F92EE;'>#胃旁路手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83198, encryptionId=a4be8319879, topicName=胃旁路手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c5417414181, createdName=zlawrance, createdTime=Thu Apr 27 07:19:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190515, encodeId=9c6b190515f4, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Tue Apr 25 18:36:09 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190500, encodeId=7c751905007c, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Apr 25 16:53:40 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1934230, encodeId=3caf193423031, content=<a href='/topic/show?id=72108319e63' target=_blank style='color:#2F92EE;'>#胃旁路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83197, encryptionId=72108319e63, topicName=胃旁路)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Sat Mar 31 23:19:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194893, encodeId=9c8d19489351, content=文章很好,值得读, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun May 07 08:16:52 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587002, encodeId=3e5b158e00252, content=<a href='/topic/show?id=a4be8319879' target=_blank style='color:#2F92EE;'>#胃旁路手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83198, encryptionId=a4be8319879, topicName=胃旁路手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c5417414181, createdName=zlawrance, createdTime=Thu Apr 27 07:19:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190515, encodeId=9c6b190515f4, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Tue Apr 25 18:36:09 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190500, encodeId=7c751905007c, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Apr 25 16:53:40 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
    2017-05-07 1e10c84am36(暂无匿称)

    文章很好,值得读

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1934230, encodeId=3caf193423031, content=<a href='/topic/show?id=72108319e63' target=_blank style='color:#2F92EE;'>#胃旁路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83197, encryptionId=72108319e63, topicName=胃旁路)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Sat Mar 31 23:19:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194893, encodeId=9c8d19489351, content=文章很好,值得读, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun May 07 08:16:52 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587002, encodeId=3e5b158e00252, content=<a href='/topic/show?id=a4be8319879' target=_blank style='color:#2F92EE;'>#胃旁路手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83198, encryptionId=a4be8319879, topicName=胃旁路手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c5417414181, createdName=zlawrance, createdTime=Thu Apr 27 07:19:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190515, encodeId=9c6b190515f4, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Tue Apr 25 18:36:09 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190500, encodeId=7c751905007c, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Apr 25 16:53:40 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1934230, encodeId=3caf193423031, content=<a href='/topic/show?id=72108319e63' target=_blank style='color:#2F92EE;'>#胃旁路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83197, encryptionId=72108319e63, topicName=胃旁路)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Sat Mar 31 23:19:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194893, encodeId=9c8d19489351, content=文章很好,值得读, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun May 07 08:16:52 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587002, encodeId=3e5b158e00252, content=<a href='/topic/show?id=a4be8319879' target=_blank style='color:#2F92EE;'>#胃旁路手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83198, encryptionId=a4be8319879, topicName=胃旁路手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c5417414181, createdName=zlawrance, createdTime=Thu Apr 27 07:19:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190515, encodeId=9c6b190515f4, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Tue Apr 25 18:36:09 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190500, encodeId=7c751905007c, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Apr 25 16:53:40 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
    2017-04-25 dhzzm

    学习了分享了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1934230, encodeId=3caf193423031, content=<a href='/topic/show?id=72108319e63' target=_blank style='color:#2F92EE;'>#胃旁路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83197, encryptionId=72108319e63, topicName=胃旁路)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Sat Mar 31 23:19:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194893, encodeId=9c8d19489351, content=文章很好,值得读, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun May 07 08:16:52 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587002, encodeId=3e5b158e00252, content=<a href='/topic/show?id=a4be8319879' target=_blank style='color:#2F92EE;'>#胃旁路手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83198, encryptionId=a4be8319879, topicName=胃旁路手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c5417414181, createdName=zlawrance, createdTime=Thu Apr 27 07:19:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190515, encodeId=9c6b190515f4, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Tue Apr 25 18:36:09 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190500, encodeId=7c751905007c, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Apr 25 16:53:40 CST 2017, time=2017-04-25, status=1, ipAttribution=)]
    2017-04-25 三生有幸9135

    学习一下谢谢分享

    0

相关资讯

2017中国国际心力衰竭大会盛大开幕!

阳春三月,春暖花开,2017年3月11日,由中国医师协会、中国医师协会心力衰竭专业委员会主办,国家心血管病中心、中国医学科学院阜外医院协办的「2017中国国际心力衰竭大会(CIHFC)暨中国医师协会心力衰竭专业委员会年会」在北京国际会议中心隆重召开。全国人大常委、中国预防医学会会长王陇德院士,中国医师协会会长张雁灵会长,国家心血管病中心主任、中国医学科学院阜外医院院长胡盛寿院士,国家心血管病中心党

中医药治疗心力衰竭 优势与局限性兼具

辨证论治是中医最重要的特色,也是临床施治的基础。充血性心力衰竭作为临床常见的急危重病证,临床表现复杂多变,我们希望从中探求中医证候演变规律及优化治疗策略。现阶段我们缺乏大规模的多中心严格设计的临床观察。目前,心力衰竭的文献报道存在病例数少以及观察疗程短的问题,影响到文献的科学性,而中医治疗本身的灵活多变性也给临床观察带来难度。不断总结经验和探索是我们当代中医的责任,任重而道远。

JAHA:磺脲类和二甲双胍单药治疗对心力衰竭风险的影响!

由此可见,与服用二甲双胍的患者相比,以磺脲类药物为主治疗糖尿病的男性患者发生心衰和心血管死亡风险更高。

心力衰竭的春天因你来,全新心力衰竭指南集锦!

一、急性心力衰竭  2016 成人急性心力衰竭护理实践指南 本指南基于目前可获得的最佳临床证据制定而成,涵盖了急性心力衰竭护理的干预措施,引用的大部分证据都与急性心力衰竭发病后紧急救治有关,是急诊室、监护室、病房、社区护理人员开展急性心力衰竭管理的临床决策参考工具。可用于:①提供临床护理的推荐意见;②制定循证护理实践方案;③制定护理实践的评价标准;④规范培训护理人员。 二、慢性

精品指南: 2016 ESC:欧洲急慢性心力衰竭指南内容要点总结

心力衰竭是由于心脏结构或功能异常导致心室充盈或射血功能受损的一组复杂临床综合征,它是各种心脏疾病的严重的终末阶段,心力衰竭发病率高,死亡率高,成为当今重要的心血管病之一,引起医学界的高度关注。2016年欧洲心脏病学会(ESC)发布了急性和慢性心力衰竭诊治指南。梅斯小编整理汇总了该指南的要点和相关证据推荐级别,供大家参考! 2016ESC:欧洲急慢性心衰诊治指南(英文版) 2016年欧洲心脏病年

2017 中国国际心力衰竭大会:郑哲教授谈心力衰竭外科治疗——从指南到临床

2017 中国国际心力衰竭大会:郑哲教授谈心力衰竭外科治疗——从指南到临床 导语:2017年由中国医师协会、中国医师协会心力衰竭专业委员会主办,国家心血管病中心、中国医学科学院阜外医院协办的中国国际心力衰竭大会在北京国际会议中心隆重召开,会议上来自中国医学科学院阜外医院的郑哲教授分享了《心力衰竭外科治疗——从指南到临床》。郑哲教授现任国家心血管病中心主任助理,中国医学科学院阜外医院院长助理。中华医