J Clincal Gastroenterology:就餐与就寝时间过短是妊娠妇女胃食管反流病的主要危险因素

2021-07-28 MedSci原创 MedSci原创

胃食管反流病 (GERD) 全世界范围内的一种常见的胃肠道疾病,怀孕妇女由于激素相关的身体机能变化导致更易患 GERD 的疾病。

      胃食管反流病 (GERD) 全世界范围内的一种常见的胃肠道疾病,怀孕妇女由于激素相关的身体机能变化导致更易患 GERD 的疾病,患病率在40% 到 85% 不等。GERD会显着的影响孕妇的生活质量,尤其是睡眠质量。因此,GERD 是怀孕期间的一个重要健康问题。据报道,较短的进餐与睡眠之间的时间间隔(MTBT)会增加酸反流的症状,然而,孕妇是不是也存在这样的影响目前还不清楚。因此,本项研究旨在评估妊娠期 GERD 的特征以及 MTBT 与 GERD 之间的关联。

 

 

      研究人员对越南嘉定人民医院产前诊所的 400 名 18 岁及以上孕妇进行了横断面研究。GERD 被定义为每周至少一次有胃灼热和/或反流的症状。反流相关失眠被定义为难以维持整夜睡眠或无法入睡。如果 MTBT 在一周中超过三分之二的天数中≤ 2 小时,则被定义为“短”。最后研究人员对所有患者进行了相关性分析。

 

      在本项研究中有 154 名 (38.5%) GERD 患者和 20 名 (13.0%) 非GERD患者存在有反流相关失眠症状。在多变量分析中,有 3 个因素与 GERD 显着相关:妊娠晚期 [(OR)=1.66;95% (CI):1.03-2.69],既往有典型反流症状(OR=9.05;95% CI:5.29-15.50),MTBT 时间短(OR=12.73;95% CI:2.92-55.45)。在没有短 MTBT、白天或夜间短 MTBT 以及白天和夜间短 MTBT 的患者亚组中,反流症状的频率逐渐增加。夜间 MTBT 也是反流相关失眠的重要危险因素(OR=4.60;95% CI:1.64-12.92)。

图:不同就餐睡眠时间间隔对于GERD的影响

 

      本项研究证实MTBT 时间过短是妊娠期 GERD的主要危险因素。这种饮食睡眠习惯与反流症状频率和反流相关失眠显着相关。

 

 

原始出处:

Quach. Et al. Short Meal-to-Bed Time Is a Predominant Risk Factor of Gastroesophageal Reflux Disease in Pregnancy. Journal of Clinical Gastroenterology.2021.

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    2021-09-25 许安
  4. 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  5. 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topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Jul 30 02:10:07 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571709, encodeId=a62515e170911, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Fri Jul 30 02:10:07 CST 2021, time=2021-07-30, status=1, ipAttribution=)]
    2021-08-23 ms6000000624048987

    特别好!

    0

  6. 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  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=1948617, encodeId=8de0194861e07, content=<a href='/topic/show?id=87828339e7a' target=_blank style='color:#2F92EE;'>#胃食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83397, encryptionId=87828339e7a, topicName=胃食管)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sat Oct 09 05:10:07 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712875, encodeId=12791e1287543, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, 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topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Jul 30 02:10:07 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571709, encodeId=a62515e170911, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Fri Jul 30 02:10:07 CST 2021, time=2021-07-30, status=1, ipAttribution=)]
    2021-07-30 zhouqu_8
  9. 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  10. 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topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Jul 30 02:10:07 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571709, encodeId=a62515e170911, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Fri Jul 30 02:10:07 CST 2021, time=2021-07-30, status=1, ipAttribution=)]
    2021-07-30 feifers

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炎症性肠病 (IBD)包括克罗恩病 (CD) 和溃疡性结肠炎 (UC) ,通常影响年轻人,包括育龄妇女。患有IBD的妊娠妇女通常会出现不良的结局例如剖腹产等。

J Clin Oncol:得了乳腺癌,是否还可以怀孕生子?

得了乳腺癌,是否还可以怀孕生子?

Environ Res:妊娠期染发剂的使用和儿童3岁时的过敏之间的关系

染发剂的使用经常会诱发过敏性接触性皮炎,在少数情况下会诱发免疫球蛋白E介导的急性荨麻疹、过敏性休克和哮喘。怀孕期间使用染发剂对后代的影响已阐明为具有致癌性,但没有研究对过敏发展的影响。

子痫前期严重威胁母婴健康,sFlt-1/PlGF比值可防范妊娠风险!

中国第七次人口普查数据显示,我国“二孩”生育率明显提升,高龄产妇、妊娠合并症以及并发症的高危人群随之增长。作为妊娠常见的并发症之一,子痫前期是妊娠期特有的全身性多系统综合征,严重威胁母婴健康。

子宫肌瘤不是善茬!12年间,美国因子宫肌瘤就诊的人次增加了129%

在 12 年的时间里(2006年~2017年),每年有数万名妇女因月经期大量出血和腹痛在急诊室就诊。