Chest:肌肉减少症在肺癌患者中的预后价值

2019-06-05 xing.T 网络

由此可见,肌肉减少症在肺癌患者中非常普遍(大约占50%),并且是SCLC患者或不同NSCLC分期患者OS的重要预测因子。

关于肌肉减少症(骨骼肌耗尽)与肺癌患者预后之间关系的证据因研究而异。近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员旨在系统地评估肌肉减少症在肺癌患者中的预后价值。

研究人员检索了Ovid MEDLINE、Embase和Cochrane对照试验中心登记中心,检索时间截止至在2018年7月23日,以确定回顾性或前瞻性队列研究。研究人员应用质量预测研究工具来评估单个研究中的偏倚风险,并评估了异质性和发表偏倚,并进行了亚组分析和敏感性分析。

研究人员纳入了13项研究(1810名参与者)。非小细胞肺癌NSCLC)患者的肌肉减少症患病率为43%,小细胞肺癌(SCLC)患者为52%。肌肉减少症与肺癌患者的总生存期(OS)较短有关(风险比[HR]为2.23; 95%CI为1.68-2.94)。这种关联存在于NSCLC(HR为2.57; 95%CI为1.79-3.68)和SCLC(HR为1.59; 95%CI为1.17-2.14)患者中。肌肉减少症是I-II期NSCLC(HR为3.23; 95%CI为1.68-6.23)和III-IV期NSCLC(HR为2.19; 95%CI为1.14-4.24)中OS较短的独立预测因子。然而,肌肉减少症不是NSCLC患者无病生存的独立预测因子(HR为1.28; 95%CI为0.44-3.69)。

由此可见,肌肉减少症在肺癌患者中非常普遍(大约占50%),并且是SCLC患者或不同NSCLC分期患者OS的重要预测因子。 

原始出处:

Ming Yang,et al.Prognostic Value of Sarcopenia in Lung Cancer A Systematic Review and Meta-analysis.chest.2019.https://doi.org/10.1016/j.chest.2019.04.115

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    2020-02-21 Smile2680
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