Nat Commun:细胞外泌体(EVs)蛋白质分析:转移性乳腺癌患者治疗反应的潜在监测指标

2021-05-10 xiaozeng MedSci原创

转移性乳腺癌(MBC)是一种包括多种不同亚型的异质性疾病,其是全球女性癌症死亡的主要原因之一。

转移性乳腺癌(MBC)是一种包括多种不同亚型的异质性疾病,其是全球女性癌症死亡的主要原因之一。尽管目前该疾病的诊断和治疗效果在不断提高,但仍有25–28%的乳腺癌(BC)患者被诊断为MBC,这些患者的5年生存率仅为27%。

在MBC患者中,实时监测和预测治疗反应对于最佳个性化治疗方案至关重要。尽管组织活检已被用于诊断MBC,但其侵袭性会带来风险和提高发病率,且在疾病进展时没有足够的可用组织进行检测。

由于计算机断层扫描(CT)在监测治疗反应方面的敏感性较低,因此不能用于疾病进展的预测。因此,迫切需要可靠、无创的工具来诊断和监测MBC。


循环细胞外泌体(EVs)的分子谱分析提供了一种有希望的无创手段来诊断、监测和预测MBC的发生发展。但是,EV蛋白标志物的分析容易被外周血中可溶性蛋白对应物的存在所混淆。

用于检测EV蛋白标记物的热泳适体传感器(TAS)

在该研究中,研究人员使用快速的、灵敏的、低成本的热泳适体传感器(TAS)来分析血浆EV的癌症相关蛋白谱,该方法不受可溶性蛋白的干扰。结果显示,EV标志物(八个EV蛋白标记的加权总和)对于MBC、非转移性乳腺癌(NMBC)和健康献血者(HD)的辨别具有很高的准确性(91.1%)。


对于正在接受治疗的MBC患者,EV标志物可以在训练、验证和前瞻性队列中准确监测患者的治疗反应,且可以作为MBC患者无进展生存期的独立预后因素。

通过TAS分析MBC、NMBC和HD中的EV蛋白

总而言之,这研究结果突出了EV在MBC监测中的潜在临床实用性。


原始出处:

Tian, F., Zhang, S., Liu, C. et al. Protein analysis of extracellular vesicles to monitor and predict therapeutic response in metastatic breast cancer. Nat Commun 12, 2536 (05 May 2021).

 

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    2022-03-08 liuli5079
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    2021-07-23 liye789132251
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    2021-05-10 146f77a4m34暂无昵称

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