Br J Cancer:荟萃分析显示糖尿病与癌症发病风险的相关性

2021-03-28 xiaozeng MedSci原创

在2015年,约有4.15亿人患有糖尿病,其中90%以上的患者患有2型糖尿病,且该患病率持续增加并影响全球所有地区和国家

在2015年,约有4.15亿人患有糖尿病,其中90%以上的患者患有2型糖尿病,且该患病率持续增加并影响全球所有地区和国家。2型糖尿病的危险因素包括遗传学、年龄、糖尿病家族史、不健康饮食、肥胖和缺乏体育锻炼。

在该研究中,研究人员旨在调查糖尿病与癌症风险之间的关联性是否年老相关,以及该关联性在年龄、体重状况或体育活动水平亚组之间的差异性。

研究人员通过分析欧洲和美国队列网络(CHANCES)的七项前瞻性队列研究数据,采用Cox风险回归法评估流行性糖尿病与癌症发病风险的相关性。并通过汇总分析和随机效应荟萃分析计算了整个队列的汇总风险评估。

糖尿病与总癌症发病风险相关性的荟萃分析

研究人员共招募了667,916个总体中位年龄为62.3(57-67)岁的参与者。在平均10.5年的随访时间中,确定了114,404例的癌症发病总病例。结果显示,糖尿病与总癌症的发病风险无关,而与男性结直肠癌发病风险呈正相关。

糖尿病与前列腺癌发病风险相关性的荟萃分析

研究人员发现,糖尿病与前列腺癌的发病风险呈负相关,但与绝经后乳腺癌无关。在探索性亚组分析中,仅在超重或肥胖的男性中,糖尿病与前列腺癌的发病风险呈负相关。


总而言之,在老年的欧洲人和美国人中,糖尿病与结直肠癌发病风险呈正相关,与前列腺癌发病风险呈负相关。


原始出处:

Amadou, A., Freisling, H., Jenab, M. et al. Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium. Br J Cancer (26 March 2021).

 

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    2021-11-15 venlin
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    2021-03-29 14657eeam65(暂无昵称)

    糖尿病患者的饮食习惯或许与肠癌发病有关,或者二者都是某些不良因素的继发疾病。

    1

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1681413, encodeId=b4c116814130a, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c12d27855367, createdName=venlin, createdTime=Mon Nov 15 12:44:20 CST 2021, time=2021-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836972, encodeId=755518369e248, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Wed Sep 15 09:44:20 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837918, encodeId=b80e183e9186d, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed Jan 12 11:44:20 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952050, encodeId=4b23952050a0, content=糖尿病患者的饮食习惯或许与肠癌发病有关,或者二者都是某些不良因素的继发疾病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=579a5131299, createdName=14657eeam65(暂无昵称), createdTime=Mon Mar 29 15:02:12 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951907, encodeId=90f295190e9a, content=得糖尿病能预防前列腺癌?, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=2, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210226/f23705539a22465dad49b185641246f4/269e005bb68348558ceb01a4a8056073.jpg, createdBy=a54d5390453, createdName=T2DM终结者, createdTime=Sun Mar 28 19:33:08 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952005, encodeId=67a295200553, content=糖尿病与癌症发病风险的相关性, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Mon Mar 29 11:12:43 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043557, encodeId=a76f104355e0b, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Mar 28 20:44:20 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
    2021-03-28 T2DM终结者

    得糖尿病能预防前列腺癌?

    2

    展开2条回复
  6. [GetPortalCommentsPageByObjectIdResponse(id=1681413, encodeId=b4c116814130a, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c12d27855367, createdName=venlin, createdTime=Mon Nov 15 12:44:20 CST 2021, time=2021-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836972, encodeId=755518369e248, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Wed Sep 15 09:44:20 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837918, encodeId=b80e183e9186d, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed Jan 12 11:44:20 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952050, encodeId=4b23952050a0, content=糖尿病患者的饮食习惯或许与肠癌发病有关,或者二者都是某些不良因素的继发疾病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=579a5131299, createdName=14657eeam65(暂无昵称), createdTime=Mon Mar 29 15:02:12 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951907, encodeId=90f295190e9a, content=得糖尿病能预防前列腺癌?, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=2, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210226/f23705539a22465dad49b185641246f4/269e005bb68348558ceb01a4a8056073.jpg, createdBy=a54d5390453, createdName=T2DM终结者, createdTime=Sun Mar 28 19:33:08 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952005, encodeId=67a295200553, content=糖尿病与癌症发病风险的相关性, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Mon Mar 29 11:12:43 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043557, encodeId=a76f104355e0b, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Mar 28 20:44:20 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
    2021-03-29 科研科研科研

    糖尿病与癌症发病风险的相关性

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1681413, encodeId=b4c116814130a, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c12d27855367, createdName=venlin, createdTime=Mon Nov 15 12:44:20 CST 2021, time=2021-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836972, encodeId=755518369e248, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Wed Sep 15 09:44:20 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837918, encodeId=b80e183e9186d, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed Jan 12 11:44:20 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952050, encodeId=4b23952050a0, content=糖尿病患者的饮食习惯或许与肠癌发病有关,或者二者都是某些不良因素的继发疾病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=579a5131299, createdName=14657eeam65(暂无昵称), createdTime=Mon Mar 29 15:02:12 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951907, encodeId=90f295190e9a, content=得糖尿病能预防前列腺癌?, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=2, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210226/f23705539a22465dad49b185641246f4/269e005bb68348558ceb01a4a8056073.jpg, createdBy=a54d5390453, createdName=T2DM终结者, createdTime=Sun Mar 28 19:33:08 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952005, encodeId=67a295200553, content=糖尿病与癌症发病风险的相关性, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Mon Mar 29 11:12:43 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043557, encodeId=a76f104355e0b, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Mar 28 20:44:20 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
    2021-03-28 misszhang

    谢谢MedSci提供最新的资讯

    0

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