ESC Heart Failure:心力衰竭患者患癌风险更高!

2021-06-29 MedSci原创 MedSci原创

近年来,随着我国生活水平逐渐提高以及人口老龄化到来,高血压、冠心病、糖尿病、老年瓣膜病等心血管疾病患病率也在逐年增长,而心力衰竭作为各种心血管病后期综合症,已成为社会广泛关注的焦点问题。

近年来,随着我国生活水平逐渐提高以及人口老龄化到来,高血压、冠心病、糖尿病、老年瓣膜病等血管疾病患病率也在逐年增长,而心力衰竭作为各种心血管病后期综合症,已成为社会广泛关注的焦点问题。

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尽管治疗方式层出不穷,然而心力衰竭死亡率仍居高不下,据数据显示,约有50%的心力衰竭患者在确诊后5年内死亡。在西欧,心力衰竭患者平均拥有5种共病。值得注意的是,越来越多证据证明,心力衰竭患者的癌症发病率也会增加,但并没有具体的流行性病学数据。近日,发表在ESC Heart Failure杂志的一项研究揭示了心力衰竭患者的癌症发病率。

这项回顾性队列研究评估了来自 2000 1 月至 2018 12 月德国 1274 家全科诊所初始诊断为心力衰竭的患者和匹配的非心力衰竭患者的癌症发病率。该研究基于IQVIA数据库的数据,包含药物处方、诊断以及基本的医疗和人口统计数据。最终共纳入100 124 名心力衰竭患者和 100 124 名无心力衰竭患者。

结果显示, 10 年的随访中,心力衰竭与癌症的发病率显著相关。心力衰竭患者的癌症发生率为 25.7%,非心力衰竭患者的癌症发生率为 16.2%。按性别划分,患有心力衰竭的女性为 28.6%,无心力衰竭的女性为 18.8%,有心力衰竭的男性为 23.2%,无心力衰竭的男性为 13.8%

有和无心力衰竭患者诊断出癌症比例

同时,该研究发现,心力衰竭和所有被评估的癌症部位之间有着较强的关联。唇癌、口腔癌和咽癌的关联最强(HR2.1095%置信区间:1.66-2.17P0.001),其次是呼吸器官(HR1.911.74-2.10P0.001)和女性患者的生殖器官(HR1.861.56-2.17P0.001)。皮肤癌,淋巴瘤消化道肿瘤,乳腺癌,泌尿生殖道相关癌症以及男性生殖器官癌症HR分别为1.831.771.751.671.64以及1.52

综上,心力衰竭患者可能面临更高的癌症风险。虽然该研究并未证明两者因果关系,只显示了心力衰竭和癌症之间的统计关系。尽管如此,这些结果使我们能够推测心力衰竭和癌症发病率增加之间可能存在因果关系。总之,该研究结果确实表明心力衰竭患者可能受益于癌症预防措施,这可能更好地保护心力衰竭患者并改善其预后,

原始出处

Christoph Roderburg et al, Heart failure is associated with an increased incidence of cancer diagnosesESC Heart Failure (2021). DOI: 10.1002/ehf2.13421

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    2021-11-03 amy0550
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    2021-12-15 sjq027
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    2021-07-01 zhaojie88
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    2021-07-01 slcumt
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    2021-07-01 lq0307
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    2021-06-29 lurry

    👌

    0

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