Gastric Cancer:术前改良的全身炎症评分对胃癌患者的预后意义

2019-08-04 不详 MedSci原创

基于术前血清白蛋白(Alb)水平和淋巴细胞与单核细胞比率(LMR)的全身炎症评分(SIS)已被证明是某些肿瘤的新型预后评分。本项研究旨在探究SIS对胃癌(GC)切除患者的预后价值。

背景
基于术前血清白蛋白(Alb)水平和淋巴细胞与单核细胞比率(LMR)的全身炎症评分(SIS)已被证明是某些肿瘤的新型预后评分。本项研究旨在探究SIS对癌(GC)切除患者的预后价值。

方法
研究人员将2008年12月至2013年12月期间接受根治性切除术的GC患者纳入本项研究。时间依赖性接收器操作特征分析(t-ROC),一致性指数(C指数)和AUC用于比较预后准确性。

结果
共有1786名患有GC的患者被纳入该研究。通过多变量分析,SIS不是一个独立的预后因素。然而,正常的Alb水平(≥40g / l)和LMR≥3.4都是GC的独立保护因素(均P<0.05)。由于正常Alb组中LMR≥3.4且LMR <3.4的患者存活率相似,我们将两个亚组合并建立了改良的SIS(mSIS)。多变量分析显示mSIS是唯一重要的独立生物标志物(P<0.05)。在整个观察期间,mSIS的t-ROC曲线和C-指数优于SIS。此外,mSIS的AUC显着高于术后3年和5年的SIS(均P <0.05)。

结论
术前mSIS是预测GC患者术后生存的新颖,简单和有用的预后评分系统,可作为术前危险分层过程的一部分,以改善临床结果的预测。

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    2019-10-03 许安
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    2020-02-08 skhzy
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