JAHA:乳腺癌患者放疗后的长期心血管风险如何?

2017-05-22 xing.T MedSci原创

由此可见,乳腺癌放疗期间心脏暴露于电离辐射会增加冠心病和心源性死亡的风险。

乳腺癌的放射治疗常涉及使心脏偶然暴露于电离辐射中。这种暴露对后续心脏病风险的影响还不确定。近日,心血管疾病领域权威杂志JAHA上发表了一篇荟萃分析文章,研究人员旨在探讨乳腺癌患者放疗与长期心血管疾病发病率和死亡率之间的关系。

研究人员检索MEDLINE(1966年1月至2015年1月)和EMBASE(1980年1月至2015年1月)数据库来查找相关文献。报告了感兴趣相关性的相对风险(RR)且估计了95%可信区间(CI)的研究被纳入研究。研究人员采用随机效应荟萃分析得到了合并的效应估计。

研究人员确定39个研究,纳入了1191371名患者进行分析。研究人员发现接受左侧放疗的患者相比于接受右侧放疗的患者,发生冠心病(RR为1.29,95%CI为1.13-1.48)、心源性死亡(RR为1.22,95%CI为1.08-1.37)和任何原因引起的死亡(RR为1.05,95%CI为1.01-1.10)的风险增加。在将放疗和无放疗的患者比较中,研究人员发现患者发生冠心病的RR为1.30(95%CI为1.13-1.49)、发生心源性死亡的RR为1.38(95%CI为1.18)。乳腺癌的放射治疗导致冠心病绝对风险增加76.4例(95%CI为36.8-130.5)和心源性死亡的绝对风险增加125.5例(95%CI为98.8-157.9)每100000人每年。在头十年期间冠状动脉心脏病风险开始增加,从第二个十年开始心源性死亡风险开始增加。

由此可见,乳腺癌放疗期间心脏暴露于电离辐射会增加冠心病和心源性死亡的风险。

原始出处:

Yun‐Jiu Cheng,et al. Long‐Term Cardiovascular Risk After Radiotherapy in Women With Breast Cancer.JAHA.2017. https://doi.org/10.1161/JAHA.117.005633

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    2017-05-26 tanxingdoctor

    学习啦谢谢分享

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue May 23 08:15:51 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201557, encodeId=92d820155ee0, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue May 23 07:53:29 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-25 cqykthl

    乳腺癌的放疗化疗都会对心脏有害

    0

  4. 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channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu May 25 08:25:40 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267454, encodeId=8c00126e454e2, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed May 24 08:12:00 CST 2017, time=2017-05-24, status=1, ipAttribution=), 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue May 23 08:15:51 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201557, encodeId=92d820155ee0, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue May 23 07:53:29 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-25 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue May 23 08:15:51 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201557, encodeId=92d820155ee0, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue May 23 07:53:29 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-24 zhaohui6731
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  7. 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channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu May 25 08:25:40 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267454, encodeId=8c00126e454e2, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed May 24 08:12:00 CST 2017, time=2017-05-24, status=1, ipAttribution=), 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue May 23 08:15:51 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201557, encodeId=92d820155ee0, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue May 23 07:53:29 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-23 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue May 23 08:15:51 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201557, encodeId=92d820155ee0, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue May 23 07:53:29 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-23 doctorJiangchao

    谢谢分享。

    0

  9. 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    2017-05-23 doctorJiangchao

    继续学习。

    0

  10. 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    2017-05-23 往日如昨

    学习了谢谢分享

    0

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