JAHA:脑微出血或脑出血卒中患者脉压升高与复发性出血性卒中风险的关系

2021-11-16 MedSci原创 MedSci原创

在脑微出血或脑出血的卒中患者中,长期升高的PP和较高的收缩压会增加随后发生出血性卒中的风险。

在伴有脑微出血或脑出血的缺血性卒中中,哪种类型的复发性卒中与脉压(PP)相关仍未明确。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究分析了脑出血高风险的缺血性卒中患者心血管事件预防数据库(PICASSO),该数据库涉及1454名受试者。

根据随访期间平均PP(mmHg)的分布(平均随访1.9年)按照四分位数将受试者进行分层:<47(第一个四分位数),48至53(第二个四分位数),54至59(第三个四分位数),并且≥60mmHg(第四个四分位数)。该研究的主要终点是出血性卒中,次要终点是缺血性卒中、任何类型的卒中和主要不良心血管事件。在受试者操作特征曲线分析下进行调整的时间依赖区域以评估平均PP的预测准确性。

血压检查的平均就诊频率为9.4±5.5次。每100人次每年的卒中发生率分别为3.14人,2.24人,5.52人和6.22人,在平均PP上升的四分位数中,主要不良心血管事件发生率分别为3.82、2.84、6.37和7.14。在存在平均动脉压的情况下,最高四分位数(调整后的风险比为6.03;95%CI为1.04-34.99)与最低四分位数相比,出血性卒中风险更高,这在平均收缩压较高时很明显。作为连续变量的较高平均PP也是出血性卒中的预测因子(1.09,1.03-1.15)。出血性卒中受试者工作特征曲线下的时间相关面积为0.79。

由此可见,在脑微出血或脑出血的卒中患者中,长期升高的PP和较高的收缩压会增加随后发生出血性卒中的风险。

原始出处:

Jong‐Ho Park,et al.Elevated Pulse Pressure and Recurrent Hemorrhagic Stroke Risk in Stroke With Cerebral Microbleeds or Intracerebral Hemorrhage.JAHA.2021.https://www.ahajournals.org/doi/10.1161/JAHA.121.022317

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Mon Nov 22 15:14:47 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268682, encodeId=5bc31268682f5, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Nov 17 23:38:53 CST 2021, time=2021-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281385, encodeId=7b68128138515, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, 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href='/topic/show?id=7ee28485472' target=_blank style='color:#2F92EE;'>#脑微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84854, encryptionId=7ee28485472, topicName=脑微出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d0b2500136, createdName=12498b08m90暂无昵称, createdTime=Wed Nov 17 23:38:53 CST 2021, time=2021-11-17, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1909933, encodeId=b93219099330f, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue May 17 02:38:53 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720430, encodeId=4e601e20430ca, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, 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href='/topic/show?id=7ee28485472' target=_blank style='color:#2F92EE;'>#脑微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84854, encryptionId=7ee28485472, topicName=脑微出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d0b2500136, createdName=12498b08m90暂无昵称, createdTime=Wed Nov 17 23:38:53 CST 2021, time=2021-11-17, status=1, ipAttribution=)]
    2021-11-22 ms6000000150556226

    好文

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Mon Nov 22 15:14:47 CST 2021, time=2021-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268682, encodeId=5bc31268682f5, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Nov 17 23:38:53 CST 2021, time=2021-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281385, encodeId=7b68128138515, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Wed Nov 17 23:38:53 CST 2021, time=2021-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319572, encodeId=450413195e26e, content=<a href='/topic/show?id=1dc13145ef8' target=_blank style='color:#2F92EE;'>#出血性卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31457, encryptionId=1dc13145ef8, topicName=出血性卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Wed Nov 17 23:38:53 CST 2021, time=2021-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393559, encodeId=410f1393559d7, content=<a href='/topic/show?id=7ee28485472' target=_blank style='color:#2F92EE;'>#脑微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84854, encryptionId=7ee28485472, topicName=脑微出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d0b2500136, createdName=12498b08m90暂无昵称, createdTime=Wed Nov 17 23:38:53 CST 2021, time=2021-11-17, status=1, ipAttribution=)]
    2021-11-22 smart Ren

    关注啦

    0

  7. 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    2021-11-17 zhaohui6731
  8. 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