J Virol:科学家发现EB病毒2型能感染人源化小鼠的T淋巴细胞并诱导B淋巴细胞瘤的产生

2018-10-30 Etrgh 病毒学界

近日，来自美国的科学家发现EBV能够感染人源化小鼠的T淋巴细胞及诱导B淋巴细胞瘤的产生。该研究成果目前已发表至《Journal of Virology》杂志，题为“Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice”。

EB病毒（Epstein-Barr virus， EBV）是属于疱疹病毒科嗜淋巴细胞病毒属的DNA病毒，根据基因型差异分析，可将EBV分为EBV 1型和EBV 2型。人是EBV感染的主要宿主，主要通过唾液传播，具有一定的传染性。研究表明，EBV是单核细胞增多症的病原体，同时，EBV感染与鼻咽癌、儿童淋巴瘤的发生有密切相关性。目前，EBV已被列为可能致癌的人类肿瘤病毒之一。近日，来自美国的科学家发现EBV能够感染人源化小鼠的T淋巴细胞及诱导B淋巴细胞瘤的产生。该研究成果目前已发表至《Journal of Virology》杂志，题为“Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice”。

研究人员使用BALB/c Rag2null IL2rγnull SIRPα人源化的小鼠模型来进行EBV-2的体内试验。通过使用EBV-2病毒感染人源化小鼠，研究人员发现，与EBV-1只感染B淋巴细胞不同的是EBV-2在机体内不仅感染T淋巴细胞，也感染B淋巴细胞。同时，研究还证实EBV-2的感染可诱导B淋巴细胞瘤的产生，并且，研究人员还发现在体外破坏EBV-2的致使B淋巴细胞瘤化能力后，EBV-2也还具备致使人源化小鼠淋巴细胞瘤产生的能力。该研究成果部分阐明了EBV-2的生物学特性，但其诱导淋巴细胞瘤化的具体机制机理，还需后续的更深一层次的研究。

原始出处：Coleman CB, Lang J, Sweet LA, et al. Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice. J Virol. 2018 Oct 12;92(21).

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2019-08-16 旅苦化文_208

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2019-07-14 ms3892185887221420

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2019-07-26 fengting15

#B淋巴细胞#

30 0
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2018-11-04 吴教授

学习了，学习了，学习了

61 0
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2018-10-31 wetgdt

#淋巴细胞#

23 0
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2018-10-31 spoonycyy

#细胞瘤#

27 0
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2018-10-31 zhenjiu129

#T淋巴细胞#

30 0
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2018-10-30 1e145228m78(暂无匿称)

学习了，谢谢作者分享!

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