Gastroenterology:JAK抑制剂不良事件风险评估

2020-01-14 MedSci MedSci原创

研究发现,JAK抑制剂治疗免疫性疾病患者感染带状疱疹的风险增加,但其他不良事件风险与安慰剂相当

Janus激酶抑制剂(JAKs)广泛用于治疗炎症性肠病和其他免疫介导疾病。近日研究人员进行了系统综述和Meta分析,以探讨tofacitinib、upadacitinib、filgotinib和baricitinib在治疗类风湿关节炎、炎症性肠病、银屑病或强直性脊柱炎患者中的安全性。

研究收集1990年1月1日到2019年7月1日间相关数据。主要结果是不良事件(AEs )和严重AEs的发生率。研究人员还估计了严重感染、带状疱疹感染、非黑色素瘤皮肤癌、其他恶性肿瘤、主要心血管事件、静脉血栓栓塞和死亡率的发病率。

研究人员收集了973项研究,其中82项包含在最终分析中,包括66159名接受JAK抑制剂的免疫疾病患者。其中三分之二的研究是随机对照试验。不良事件发生率为42.65/100人-年,严重AEs事件发生率为9.88/100人-年。严重感染、带状疱疹感染、恶性肿瘤和重大心血管事件的发生率分别为2.81/100人-年、2.67/100人-年、0.89/100人-年和0.48/100人-年。与安慰剂或活性对照组相比,使用JAK抑制剂的患者的死亡率没有增加(相对风险为0.72)。Meta分析显示,接受JAK抑制剂的患者感染带状疱疹的风险显著增加(相对风险为1.57)。

研究发现,JAK抑制剂治疗免疫性疾病患者感染带状疱疹的风险增加,但其他不良事件风险与安慰剂相当。

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    2020-09-09 jklm09
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    2020-12-08 许安
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