JACC:冠脉18F氟化钠的摄入可预测冠心病患者心梗风险

2020-06-22 MedSci原创 MedSci原创

目前尚缺乏可靠的方法预测冠心病患者的心肌梗死,冠状动脉18F氟化钠(18F-NaF)正电子发射断层扫描(PET)可评估动脉粥样硬化活动。本研究旨在评估18F-NaF-PET是否能预测心肌梗死,并为目前

目前尚缺乏可靠的方法预测冠心病患者的心肌梗死,冠状动脉18F氟化钠(18F-NaF)正电子发射断层扫描(PET)可评估动脉粥样硬化活动。本研究旨在评估18F-NaF-PET是否能预测心肌梗死,并为目前的危险分层方法提供额外的预后信息。

本研究对确诊为冠心病的患者进行18F-NaF-PET检测,并随访超过42个月观察是否出现心梗。最终共纳入分析293名冠心病患者(平均年龄65 ± 9岁,男性占84%),其中203名患者出现冠脉18F-NaF活性增高。心梗患者仅出现在冠脉18F-NaF活性增高的患者中(20/203,p < 0.001)。患者CMA(冠脉微钙化活性)>1.56的心梗发生风险或增高7倍以上(HR:7.1; 95% cl: 2.2 - 25.1; p = 0.003),且独立于性别、年龄、传统危险因素、节段受累和冠状动脉钙评分、冠状动脉支架的存在、冠状动脉狭窄、REACH和SMART评分、杜克冠状动脉疾病指数和近期心肌梗死。

研究结果显示,对于确诊冠心病的患者来说,18F氟化钠正电子发射断层扫描可以强有力地预测心梗的发生。

原始出处:

Jacek K et al.Coronary 18F-Sodium Fluoride Uptake Predicts Outcomes in Patients With Coronary Artery Disease.JACC.2020 June.

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    2020-12-08 hbwxf
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