J Clin Periodontol:唾液IL-1β水平用于估计非吸烟者和吸烟者牙周炎发生概率的准确性

2020-05-31 网络 网络

本文检测唾液白细胞介素(IL)1β水平,通过吸烟习惯进行区分,并基于模型预测牙周炎的发生概率。

本文检测唾液白细胞介素(IL)1β水平,通过吸烟习惯进行区分,并基于模型预测牙周炎的发生概率。

本研究共招募了141名参与者,62名牙周健康对照和79名牙周炎患者。50名患者接受非手术牙周治疗,且2个月内的牙周状况有显着改善。使用Luminex仪器检测唾液样本中的IL-1β水平。利用二元Logistic回归模型,将未治疗的牙周炎与牙周健康者(第一次建模),未治疗的牙周炎与治疗的牙周炎者(第二次建模)进行区分,并区分非吸烟者和吸烟者。计算曲线下面积(AUC)和分类测量值。

结果发现,在第一个模型中,IL-1β显示非吸烟者的AUC值为0.830,吸烟者为0.689(精度分别为77.6%和70.7%)。第二个预测模型显示,非吸烟者的AUC值为0.671,吸烟者为0.708(精度分别为70.0%和75.0%)。

因此,唾液IL-1β水平在区分未治疗的牙周炎患者和牙周健康者时具有出色的诊断能力,在吸烟者中的预测能力会降低。唾液IL-1β水平也具有区分未经治疗的牙周炎和治疗的牙周炎时的能力。

原文出处:

NoraArias‐Bujanda, Diagnostic accuracy of IL1β in saliva: The development of predictive models for estimating the probability of the occurrence of periodontitis in non‐smokers and smokers, Journal of clinical periodontology, 2020 June,doi:10.1111/jcpe.13285

 

 

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    2020-08-01 feather89
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    2020-06-02 rgjl
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    2020-06-02 jjjiang0202
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