Gut:好好刷牙,预防癌症!牙周病会增加患癌风险!

2020-07-25 生物技术君 中国生物技术网

如果不想得癌症,除了保持健康的生活习惯外,恐怕要多刷刷牙或多用牙线了!近日,发表在《Gut》上的一项新研究中,报告说:牙龈不健康,患某些类型癌症的风险更高。

如果不想得癌症,除了保持健康的生活习惯外,恐怕要多刷刷牙或多用牙线了!近日,发表在《Gut》上的一项新研究中,来自美国哈佛大学T.H. Chan公共卫生学院和中山大学附属第一医院等研究机构的研究人员报告说:牙龈不健康,患某些类型癌症的风险更高。

这是一项前瞻性研究,结论基于两项长期健康研究的数据(即口腔微生物组在胃癌中的作用,以及口腔细菌与食道癌的潜在联系),牙龈疾病史似乎会增加52%的胃癌和43%的食道癌风险。

该研究称,与没掉牙的人相比,损失两颗及以上牙齿的人患癌症风险也增加了,胃癌和咽喉癌的风险分别上升33%和42%。

该研究通讯作者、哈佛大学T.H. Chan公共卫生学院临床流行病学和营养学助理教授Mingyang Song说:“患有牙周病和牙齿脱落较多的人患这两种胃肠道癌的风险更高,即使在调整了其他主要风险因素后也是如此。”

如果这些发现得到证实,那么应该引起我们重视。据第四次全国口腔健康流行病学调查结果显示,我国中年人牙周健康状况堪忧:35-44岁居民中,口腔内牙石检出率为96.7%,男性高于女性;牙龈出血检出率为87.4%,男性高于女性。

在这项研究中,研究人员分析了来自护士健康研究(1992-2014)的98459名女性和来自健康专业人员随访研究(1988–2016)的49685名男性的牙周疾病史与牙齿脱落情况与食道和胃腺癌风险的关系。

在22到28年的随访期间,他们记录了199例食管腺癌和238例胃腺癌。研究结果显示,总体而言,有牙龈疾病史的人与从未有牙周疾病的相比,无论有无牙齿损失,其患喉癌的风险增加了59%。

在胃癌方面则有一些不同:未掉牙的牙龈疾病患者罹患胃癌的风险增加了50%,而掉了一颗或多颗牙齿的人罹患胃癌的风险增加68%。

美国癌症协会流行病学研究主任Peter Campbell说:“当然,口腔、食道和胃都是相连的。它们是消化系统的重要组成部分。一个器官出现疾病标志物与另一种疾病(如癌症)相关联就不足为奇了。”

Song说,牙龈疾病引起的炎症可能是增加癌症风险的一个因素。

他解释说:“牙周病患者往往具有较高的全身性炎症,这是癌症发展的潜在机制之一。”研究人员指出,不良的口腔健康状况也可能会促进口腔和牙龈中细菌的生长,从而导致癌症。Campbell说:“根据这项研究以及其他类似的研究,似乎导致牙齿脱落和牙龈疾病的某些细菌和相关病原体也与胃部和食道肿瘤有关。”

Song补充说,在这项研究中,与牙龈疾病有关的癌症风险与吸烟无关,这意味着口腔健康状况较差的吸烟者可能面临更高的胃肠道癌症风险。

Song和Campbell认为,牙龈健康状况变糟的时间越长,患癌症的风险就越大。

Campbell说:“牙周病持续时间越长,患这些癌症的风险就越高,这似乎是合理的。这种相关性的部分原因可能仅仅是与年龄有关,衰老本身就是一个强大的风险因素,但我们倾向于能更好地解释这个问题。”

因此,如果你有牙龈病史并希望降低潜在的癌症风险,Campbell建议你定期去看牙医,好好照顾你的口腔健康,了解癌症的迹象和症状,并接受适合年龄的癌症筛查。研究人员呼吁对这种可能的癌症风险进行更多的研究,包括临床试验。

原始出处:

Chun-Han Lo 1 2, Sohee Kwon 2 3, Liang Wang 1 4,et al.Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study.Gut. 2020 Jul 20;gutjnl-2020-321949. doi: 10.1136/gutjnl-2020-321949.

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    2020-08-26 zhaojie88
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    2020-07-27 jeanqiuqiu
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    2020-07-27 lq0307
  8. [GetPortalCommentsPageByObjectIdResponse(id=2061950, encodeId=60b120619501a, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Sep 22 21:35:10 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813576, encodeId=e8888135e65f, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Aug 26 22:05:07 CST 2020, time=2020-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282316, encodeId=e8971282316f7, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Jul 27 08:35:10 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413473, encodeId=c84214134e319, content=<a href='/topic/show?id=3f225299942' target=_blank style='color:#2F92EE;'>#患癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52999, encryptionId=3f225299942, topicName=患癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2c2959841, createdName=zzc2212, createdTime=Mon Jul 27 08:35:10 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451310, encodeId=154c1451310a8, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Jul 27 08:35:10 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488073, encodeId=6d4d14880e306, content=<a href='/topic/show?id=5c699e46010' target=_blank style='color:#2F92EE;'>#防癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97460, encryptionId=5c699e46010, topicName=防癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6d78400961, createdName=jeanqiuqiu, createdTime=Mon Jul 27 08:35:10 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601468, encodeId=296316014688b, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Mon Jul 27 08:35:10 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804557, encodeId=6e1e80455eca, content=口腔健康很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Sat Jul 25 22:59:43 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804543, encodeId=573580454346, content=普及, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2f6Tmc64KydltDQqJVEYZgFJdSdjq8h8icOQLm6BiaIO6Vkek7TtOzFNJDbMDo3cr5LUfIcPOHWO9E/0, createdBy=3dd11927311, createdName=1e0bfbefm39(暂无匿称), createdTime=Sat Jul 25 19:51:21 CST 2020, time=2020-07-25, status=1, ipAttribution=)]
    2020-07-25 1240394fm61暂无昵称

    口腔健康很重要

    0

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    2020-07-25 1e0bfbefm39(暂无匿称)

    普及

    0

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