mRNA疫苗揭密：脂质纳米颗粒的大小与免疫原性的关系

2021-07-25 J Control Release J Control Release

近期，Luis A. Brito团队在

近期，Luis A. Brito团队在《Journal of Controlled Release》期刊2021年第335期上以题为“Impact of lipid nanoparticle size on mRNA vaccine immunogenicity”发表封面文章，表明脂质纳米颗粒的大小会影响免疫原性。疫苗被广泛认为是20世纪最伟大的公共卫生成就之一，每年挽救了数百万人的生命。目前已有针对30种不同病原体的疫苗，但仍有许多疾病没有疫苗。因此，发展新的疫苗技术显得尤为重要。为了达到既能解决未得到满足的医疗需求，又能迅速开发针对新病原体的疫苗这两个目的，mRNA疫苗是不二之选。 mRNA疫苗通过传递编码病毒抗原的mRNA，在体内表达抗原，激发机体免疫应答，发挥预防或治疗疾病的作用。因此，一旦我们拥有抗原序列，就可以快速研发相应疫苗。SARS-CoV-2疫苗在病毒基因组测序公布后45天，就有相应的mRNA疫苗进入到临床研究。mRNA的优越性可见一斑。目前，常用脂质纳米颗粒（LNP）递送mRNA。LNPs由可电离脂质、磷脂、胆固醇和聚乙二醇脂质组成。该团队发现，蛋白质表达量不是

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2021-09-11 12498b3em08(暂无昵称)

#RNA疫苗#

21 0
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2021-07-26 ms3117646317107274

#纳米颗粒#

44 0
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2021-07-26 ms5353107019656438

#免疫原性#

54 0
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2021-07-25 ms3000001999514966

理学物理心电图

59 0
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2021-07-25 weigq

消耗2积分！！！

101 0
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