JACC:N末端B型利钠肽前体可以预测瓣膜性心脏病的死亡风险

2020-04-10 MedSci原创 MedSci原创

N末端B型利钠肽前体(NT-proBNP)可反映瓣膜性心脏病(VHD)患者的早期预后。本研究旨在探讨NT-proBNP与老年VHD患者死亡率的关系。

N末端B型利钠肽前体(NT-proBNP)可反映瓣膜性心脏病(VHD)患者的早期预后。本研究旨在探讨NT-proBNP与老年VHD患者死亡率的关系。

本研究共纳入分析了5983名老年(年龄>60岁)中重度VHD患者,并进行了超声心动图和NT-proBNP检测,经过1年的随访,有561名(9.4%)患者死亡,除了二尖瓣狭窄外,不同心脏瓣膜病患者的死亡率(p<0.001)随着NT-proBNP比值的增大,相对危险性也呈单调增加。较高的NT-proBNP比值与患者的死亡率呈独立相关性(p<0.001)。不同VHD亚型的死亡风险增高均与NT-proBNP比值升高相关,其中主动脉瓣狭窄的相关性最强。在包含传统危险因素的预测算法中加入NT-proBNP比率可以改进患者预后的预测。

研究结果显示,N末端B型利钠肽前体可以预测瓣膜性心脏病的死亡风险。

原始出处:

Bin Z et al.Prognostic Value of N-Terminal Pro–B-Type Natriuretic Peptide in Elderly Patients With Valvular Heart Disease.JACC.2020 Apr.

 

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    2020-05-04 hbwxf
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