AJG: 新冠肺炎感染患者胃肠道症状的患病率分析

2022-01-21 MedSci原创 MedSci原创

新冠一般指新型冠状病毒肺炎。 新型冠状病毒肺炎(Corona Virus Disease 2019,COVID-19),简称“新冠肺炎”,世界卫生组织命名为“2019冠状病毒病”。

严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)感染被称为冠状病毒-19疾病(COVID-19)或称为新冠肺炎。新冠肺炎的发病可以从无症状到迅速进展到危及生命的程度。严重的COVID-19的特点是低氧血症、呼吸功能不全,并最终导致多器官衰竭。SARS-CoV-2病毒也可能感染胃肠道(GI),消化道受累会出现恶心、呕吐、腹痛等。因此,本项研究旨在试图评估COVID-19患者中消化道症状的流行率以及消化道症状对呼吸道病变的风险。

 

本项研究被称为GI-COVID-19研究,它是是一项前瞻性、多中心、对照研究。研究人员对所有入院时招募和未确诊 COVID-19 的患者进行了数据收集,并在入院时和1个月后使用经过验证的胃肠道症状评定量表问卷询问胃肠道症状。

 

该研究总共纳入了2036名住院患者。共有871名患者(575 名COVID(+)296 名COVID(-))被纳入初步分析。COVID-19 阳性患者(59.7%;343/575 名患者)比对照组(43.2%;128/296 名患者)更频繁地出现胃肠道症状(P < 0.001)。与对照组相比,COVID-19阳性 患者更易出现恶心、腹泻、稀便和排便紧迫感的现象。在1个月的随访后,研究人员发现入院时出现胃肠道症状的 COVID-19 患者的胃肠道症状程度会有所减轻,但恶心仍然比较厉害。与 COVID-19 持续恶心显着相关的因素是女性、肥胖、呼吸困难和C反应蛋白水平升高。

图:新冠肺炎患者发生胃肠道症状的概率

本项研究的研究结果证实住院 COVID-19阳性患者的胃肠道症状患病率高于先前报道的。全身和呼吸道症状通常与胃肠道疾病的发生有关。在 COVID-19 感染消退后,恶心可能会持续存在。

原始出处:

Marasco, Giovanni. Et al. Prevalence of Gastrointestinal Symptoms in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results of the Prospective Controlled Multinational GI-COVID-19 Study. The American Journal of Gastroenterology.2022.

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    2022-01-24 minzju5052
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    2022-03-13 zhwj
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    2022-02-07 cherry羽

    学习了

    0

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