诺华将以16亿美元收购IFM Tre以强化其抗炎药物组合研发管线

2019-04-01 不详 MedSci原创

诺华公司将以16亿美元收购IFM Therapeutics的IFM Tre部门。诺华将支付3.1亿美元的预付款,以获得IFM Tre的NLPR3拮抗剂组合,其中包括一个临床和两个临床前研究。

诺华公司将以16亿美元收购IFM Therapeutics的IFM Tre部门。诺华将支付3.1亿美元的预付款,以获得IFM Tre的NLPR3拮抗剂组合,其中包括一个临床和两个临床前研究。

这些研究包括用于治疗多种慢性炎症性疾病(包括动脉粥样硬化和非酒精性脂肪性肝炎(NASH))的系统性拮抗剂IFM-2427,用于治疗炎性肠病的临床前期药物分子,以及用于治疗中枢神经系统(CNS)临床前阶段的渗透性药物分子。

IFM Therapeutics首席执行官兼联合创始人Gary D. Glick表示:"自2015年成立IFM以来,我们的团队一直致力于先天免疫系统以发现新的治疗靶点,建立下一代小分子药物组合。"

"基于大量的临床前和转化数据,我们认为抑制NLRP3代表了一种预防过度炎症的新疗法,可以用于抑制代谢、纤维化、自身免疫和神经系统疾病的进展。"

IFM Tre通过选择性抑制NLRP3介导的炎症来调控先天免疫系统,使其他免疫途径不受抑制并发挥正常的抗菌活性。

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    2019-05-25 一天没事干

    很好的学习机会

    0

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    2019-04-03 lqvr
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