Pulm Circ:血清生存素代表了反映CHD-PAH患者可操作性的候选生物标志物

2020-04-07 MedSci原创 MedSci原创

肺动脉高压(PAH)的可逆性决定了先天性心脏病(CHD)合并PAH的治疗难易性,但缺乏评价可逆性的方法。本研究旨在研究不可逆PAH大鼠血清生存素水平,探讨其作为评估CHD患者PAH可逆性的生物标志物的

肺动脉高压(PAH)的可逆性决定了先天性心脏病(CHD)合并PAH的治疗难易性,但缺乏评价可逆性的方法。本研究旨在研究不可逆PAH大鼠血清生存素水平,探讨其作为评估CHD患者PAH可逆性的生物标志物的潜力。

 

不可逆性PAH大鼠的特点是内膜形成的突出梗阻性病变,与细胞凋亡减少和生存素表达增加有关,而可逆性PAH大鼠的特点是内膜肥大导致轻度闭塞,细胞凋亡增加,生存素表达不变。此外,与可逆性PAH大鼠和对照组大鼠相比,不可逆性PAH大鼠的血清survivin明显增加,证实了血清survivin与肺部survivin表达呈正相关。再者,不可逆性CHD-PAH患者的术前血清survivin明显高于可逆性CHD-PAH患者,且术前血清survivin与BNP、术前肺血管阻力指数、术后平均肺动脉压之间显著相关。

 

总之,生存素水平升高是不可逆性PAH的一个特征,血清生存素代表了反映CHD-PAH患者可操作性的候选生物标志物。

 

原始出处:

 

Gang LiHan Zhang, et al., The expression of survivin in irreversible pulmonary arterial hypertension rats and its value in evaluating the reversibility of pulmonary arterial hypertension secondary to congenital heart disease. Pulm Circ. 2019 Jul-Sep; 9(3): 2045894019859480.

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    2020-04-09 hb2010ye
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