Dig Dis Sci: 炎症性肠病不会影响死亡率,但会增加急性心肌梗死患者的住院时间

2021-01-27 MedSci原创 MedSci原创

炎性肠病(IBD)是一种由免疫介导的慢性组织损伤的胃肠道(GI)炎性病症,主要包括溃疡性结肠炎(UC)和克罗恩病(CD)。

       炎性肠病(IBD)是一种由免疫介导的慢性组织损伤的胃肠道(GI)炎性病症,主要包括溃疡性结肠炎(UC)和克罗恩病(CD)。由于其他免疫性疾病如类风湿关节炎(RA),银屑病,和系统性红斑狼疮与血管事件发生存在正相关性,因此,研究人员怀疑IBD的自身免疫特性与心血管(CV)事件的发生风险也存在相关性。而且,丹麦的一项全国性队列研究对86790例初发心梗(MI)的患者进行了研究,其中1030例患有IBD(75.9%UC和24.1%CD),发现MI时IBD发作与MI30内天复发风险增加相关。本项研究旨在调查IBD患者的心肌梗塞(MI)临床结局。

 

 

      研究人员使用1998年至2010年美国全国住院患者样本数据进行了横断面研究。对所有合格的MI患者比较了有或没有IBD诊断的临床结局。对数据进行单因素分析后,再校正混杂因素进行相关分析,使用多因素logistic回归确定UC和CD对院内MI死亡率的影响。

 

 

      本项研究共纳入2629161例MI患者,其中3607例UC和3784例CD患者。UC(OR,1.12; 95%CI 0.98–1.29)和CD(OR 0.99; 95%CI 0.86-1.15)都不影响MI患者的院内死亡率。合并或不合并UC的MI患者的院内死亡率(7.75%vs. 7.05%; p = 0.25)或合并或不合并CD的MI患者的院内死亡率之间没有差异(6.50%vs.6.59%; p = 0.87)。与非IBD患者相比,IBD患者的住院时间(LOS)更长,UC患者的医疗总费用更高($ 65182 vs. $ 53542;p <0.001)。

 

 

      本项研究通过回顾性分析表明,IBD不会影响心肌梗死的院内死亡率。但是,患有IBD的MI患者的LOS较长。UC患者的总住院费用要高于没有IBD的MI患者。

 

 

 

原始出处:

Preetika Sinh. Et al. Inflammatory Bowel Disease Does Not Impact Mortality but Increases Length of Hospitalization in Patients with Acute Myocardial Infarction. Digestive Diseases and Sciences.2021.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2013573, encodeId=0a7a20135e3b3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 12 02:20:25 CST 2021, time=2021-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407140, encodeId=1716140e14092, content=<a href='/topic/show?id=d0db264464a' target=_blank style='color:#2F92EE;'>#住院时间#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26446, encryptionId=d0db264464a, topicName=住院时间)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfbf2593024, createdName=crystal0563, createdTime=Fri Jan 29 04:20:25 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547410, encodeId=3770154e4105a, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri Jan 29 04:20:25 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920479, encodeId=39819204e9e4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210128/d3071b147074431dbf0ff7edea469c25/ad9ddcb8fa4846c68f31995e000a6ef1.jpg, createdBy=a8881926001, createdName=hfq, createdTime=Wed Jan 27 23:56:13 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920333, encodeId=b44892033372, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54f85456521, createdName=ms4000002029592022, createdTime=Wed Jan 27 16:47:07 CST 2021, time=2021-01-27, status=1, ipAttribution=)]
    2021-04-12 zhaojie88
  2. [GetPortalCommentsPageByObjectIdResponse(id=2013573, encodeId=0a7a20135e3b3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 12 02:20:25 CST 2021, time=2021-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407140, encodeId=1716140e14092, content=<a href='/topic/show?id=d0db264464a' target=_blank style='color:#2F92EE;'>#住院时间#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26446, encryptionId=d0db264464a, topicName=住院时间)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfbf2593024, createdName=crystal0563, createdTime=Fri Jan 29 04:20:25 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547410, encodeId=3770154e4105a, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri Jan 29 04:20:25 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920479, encodeId=39819204e9e4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210128/d3071b147074431dbf0ff7edea469c25/ad9ddcb8fa4846c68f31995e000a6ef1.jpg, createdBy=a8881926001, createdName=hfq, createdTime=Wed Jan 27 23:56:13 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920333, encodeId=b44892033372, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54f85456521, createdName=ms4000002029592022, createdTime=Wed Jan 27 16:47:07 CST 2021, time=2021-01-27, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2013573, encodeId=0a7a20135e3b3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 12 02:20:25 CST 2021, time=2021-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407140, encodeId=1716140e14092, content=<a href='/topic/show?id=d0db264464a' target=_blank style='color:#2F92EE;'>#住院时间#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26446, encryptionId=d0db264464a, topicName=住院时间)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfbf2593024, createdName=crystal0563, createdTime=Fri Jan 29 04:20:25 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547410, encodeId=3770154e4105a, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri Jan 29 04:20:25 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920479, encodeId=39819204e9e4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210128/d3071b147074431dbf0ff7edea469c25/ad9ddcb8fa4846c68f31995e000a6ef1.jpg, createdBy=a8881926001, createdName=hfq, createdTime=Wed Jan 27 23:56:13 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920333, encodeId=b44892033372, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54f85456521, createdName=ms4000002029592022, createdTime=Wed Jan 27 16:47:07 CST 2021, time=2021-01-27, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2013573, encodeId=0a7a20135e3b3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 12 02:20:25 CST 2021, time=2021-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407140, encodeId=1716140e14092, content=<a href='/topic/show?id=d0db264464a' target=_blank style='color:#2F92EE;'>#住院时间#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26446, encryptionId=d0db264464a, topicName=住院时间)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfbf2593024, createdName=crystal0563, createdTime=Fri Jan 29 04:20:25 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547410, encodeId=3770154e4105a, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri Jan 29 04:20:25 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920479, encodeId=39819204e9e4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210128/d3071b147074431dbf0ff7edea469c25/ad9ddcb8fa4846c68f31995e000a6ef1.jpg, createdBy=a8881926001, createdName=hfq, createdTime=Wed Jan 27 23:56:13 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920333, encodeId=b44892033372, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54f85456521, createdName=ms4000002029592022, createdTime=Wed Jan 27 16:47:07 CST 2021, time=2021-01-27, status=1, ipAttribution=)]
    2021-01-27 hfq

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2013573, encodeId=0a7a20135e3b3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 12 02:20:25 CST 2021, time=2021-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407140, encodeId=1716140e14092, content=<a href='/topic/show?id=d0db264464a' target=_blank style='color:#2F92EE;'>#住院时间#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26446, encryptionId=d0db264464a, topicName=住院时间)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfbf2593024, createdName=crystal0563, createdTime=Fri Jan 29 04:20:25 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547410, encodeId=3770154e4105a, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Fri Jan 29 04:20:25 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920479, encodeId=39819204e9e4, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210128/d3071b147074431dbf0ff7edea469c25/ad9ddcb8fa4846c68f31995e000a6ef1.jpg, createdBy=a8881926001, createdName=hfq, createdTime=Wed Jan 27 23:56:13 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920333, encodeId=b44892033372, content=学习到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54f85456521, createdName=ms4000002029592022, createdTime=Wed Jan 27 16:47:07 CST 2021, time=2021-01-27, status=1, ipAttribution=)]
    2021-01-27 ms4000002029592022

    学习到了

    0

相关资讯

Eur Heart J:心肌梗死患者LDL-C降低和他汀类药物治疗强度与主要不良结局

MI后早期LDL-C降低程度较大和高强度他汀类药物治疗,与降低所有CV结局和全因死亡率的风险有关。这些结果支持了临床试验数据,提示在MI后早期降低LDL-C具有最大益处。

Circulation:碾碎服用是否可提高普拉格雷对心肌梗死患者的疗效?

专家建议,拟行经皮冠状动脉介入治疗的ST段抬高型心肌梗死患者,可在pPCI前服用P2Y12抑制剂,本研究旨在评估ST段抬高型心肌梗死患者服用整片或碾碎的普拉格雷对冠脉再灌注的影响。

郑杨:关注冠脉造影正常的急性心肌梗死——MINOCA的诊断与管理

临床中常常遇到这样的情形,患者由于胸痛怀疑心梗就诊,被送至导管室后确诊冠脉正常或有轻度冠脉病变,但不足以支持诊断为冠脉阻塞性病变。通常认为,这部分患者未来发生心血管事件的风险相较明确阻塞性病变患者较低

NAT COMMUN:“有毒”的嗜酸性粒细胞可改善心肌梗死后的心脏功能

体外培养来自WT小鼠或重组mEar1蛋白的嗜酸性粒细胞,而非来自IL4缺失小鼠的嗜酸性粒细胞,可有效纠正嗜酸性粒细胞缺失的ΔdblGATA小鼠加重的心脏功能障碍。

Circulation:心肌梗死预后的“性别歧视”!

Ezekowitz等人推测心肌梗塞(MI)治疗中的性别差异可能会随着时间而改变,尤其是出现心力衰竭的风险。为了阐明两性之间的差异,研究人员建立了一些列的多变量模型来进行探索。

Circulation:不同心肌梗死定义对发病率、治疗和预后的影响

在ISCHEMIA试验中,与保守治疗方案相比,对于稳定性缺血性心脏病和中度/重度心肌缺血的患者,一开始就给予侵入性治疗并不能显著降低心血管事件发生率或全因死亡率。复合心血管终点最常见的事件是心肌梗死。