Neurology:Erenumab预防偏头痛的血管安全性

2019-12-20 xing.T MedSci原创

由此可见,用Erenumab选择性阻断经典降钙素基因相关肽受体进行偏头痛预防12周内的血管安全性可与安慰剂媲美,并且随着时间的推移,病例没有增加。需要进一步研究来验证Erenumab对偏头痛患者的长期安全性。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在所有偏头痛预防研究中评估Erenumab的心血管、脑血管和外周血管安全性。 

研究人员对4项在慢性或发作性偏头痛患者中进行的Erenumab及其开放标签扩展的双盲、安慰剂对照研究的血管不良事件(AEs)和血压数据进行整合。通过急性偏头痛特异性药物的使用和基线血管危险因素的数量进行亚组分析。研究人员使用标准化检索词来识别血管(心血管、脑血管或外周血管)AE。

在安慰剂对照研究中,2443例患者每月皮下注射一次安慰剂(n=1043)、70 mg Erenumab(n=893)或140 mg Erenumab(n=507)。不管基线时使用急性偏头痛特异性药物或血管危险因素如何,安慰剂组和Erenumab治疗组的AE发生率均相似。据报道,高血压AEs的患者分别为0.9%(安慰剂)、0.8%(70mg Erenumab)和0.2%(140mg Erenumab)。在双盲和开放标签治疗中血管AE相似可能与替代病因混杂因素有关。独立委员会审查的18例事件中,有4例患者被判定为心血管起源:2例死亡和2例血管事件。所有4个心血管事件判定阳性的个体均发生在开放标签的Erenumab治疗期间。

由此可见,用Erenumab选择性阻断经典降钙素基因相关肽受体进行偏头痛预防12周内的血管安全性可与安慰剂媲美,并且随着时间的推移,病例没有增加。需要进一步研究来验证Erenumab对偏头痛患者的长期安全性。  
 
原始出处:

David Kudrow,et al.Vascular safety of erenumab for migraine prevention.Neurology.2019.https://n.neurology.org/content/early/2019/12/18/WNL.0000000000008743

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