Brain:新冠可能引发吉兰-巴雷综合征

2021-09-24 K.K MedSci原创

研究表明,新冠感染可能在极少数情况下先于吉兰-巴雷综合征,但是否存在真正的关联或因果关系仍需确定。

牛津大学在《大脑》上发表的一篇新论文发现,新冠感染可能会促使吉兰-巴雷综合症的发生。

Linda W G Luijten et al, Guillain-Barré syndrome after SARS-CoV-2 infection in an international prospective cohort study, Brain (2021). DOI: 10.1093/brain/awab279

吉兰-巴雷综合征是一种自身免疫性疾病,患者的免疫系统会攻击神经,导致肌肉无力,偶尔会出现瘫痪。该病可能持续数周或数年,这种疾病相对罕见(在美国每年有3000-6000人患上这种疾病)。

自这一流行病开始以来,医生已经报告了90多例可能是新冠感染患上吉兰-巴雷综合征。新冠是否是另一个潜在的感染性诱因,或者报告的病例是否是巧合,目前还不清楚。研究人员从2020年1月30日~5月30日对患者进行了研究。在此期间,来自中国、丹麦、法国、希腊、意大利、荷兰、西班牙、瑞士和英国的约49名吉兰-巴雷综合症患者被纳入研究。

在大流行开始4个月中的吉兰-巴雷综合征患者中,有22%的患者之前曾感染过新冠病毒,这些病人都在50岁以上,65%病人经常出现面瘫,并患有脱髓鞘形式的吉兰巴雷综合征。入院时,73%有新冠感染且患有吉兰巴雷综合征的患者炎症标志物增加。虽然新冠感染和吉兰-巴雷综合征之间不可能有很强的关联,但新冠感染有时可能会导致病人患上吉兰-巴雷综合征。研究人员还强调,与去年相比,他们没有发现头四个月有更多的病人患有吉兰-巴雷综合症。

论文作者之一Bart C. Jacobs说:"研究表明,新冠感染可能在极少数情况下先于吉兰-巴雷综合征,但是否存在真正的关联或因果关系仍需确定。"

原文链接:

Linda W G Luijten et al, Guillain-Barré syndrome after SARS-CoV-2 infection in an international prospective cohort study, Brain (2021). DOI: 10.1093/brain/awab279

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    2022-07-21 ms8000001040615857

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    2021-09-24 zerohahaha

    学习了

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