Neurology:急性缺血性卒中患者血压与预后之间的关系随时间变化

2020-07-09 MedSci原创 MedSci原创

SBP与功能预后之间的关系可能取决于卒中发作的时间。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在评估在缺血性卒中的急性期收缩压(SBP)与卒中结局之间的关系是否随卒中发作后的时间推移而变化。

研究人员回顾性地分析了发病后6小时内因缺血性卒中住院的患者。在八个时间点(发病后1、2、4、8、16、24、48和72小时)收集了SBP数据。主要的功能结局指标为不良结局,定义为卒中后3个月修正后的Ranki评分(mRS)评分>2。在每个时间点构建线性和二分类模型以评估SBP与结局之间的关系。

在2546名患者中,有728名(28.6%)患者的预后较差。SBP,无论是线性的还是二分类指标,都对功能结局有重要影响,除了在发作后4小时。在发病后最初的2小时内,SBP与功能预后呈非线性的U型关联,SBP约为165mmHg的患者预后较差。二分类模型发现具有更好的模型拟合。发病后8–24小时,SBP与功能结局呈线性关系。在发病后48-72小时内,SBP与功能预后呈J型关联,并且预测的不良预后概率在SBP约为125mmHg的患者中最低。这些关联在各种敏感性分析中相对一致。

这项研究表明,SBP与功能预后之间的关系可能取决于卒中发作的时间。

原始出处:

Ji-Ah Shin.et al.Relationship between blood pressure and outcome changes over time in acute ischemic stroke.Neurology.2020.https://doi.org/10.1212/WNL.0000000000010203

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    2020-12-15 yinhl1978
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    2020-07-09 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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