Eur Heart J:身体虚弱与心血管结局的关系

2021-07-31 MedSci原创 MedSci原创

在非CHD患者中,身体虚弱是MACE发生发展的一个危险因素。需要努力识别非CHD患者的虚弱状态,并采取干预措施来限制或逆转虚弱状态,如果成功,可能会限制随后的不良心血管事件。

身体虚弱是没有冠心病(CHD)老年人常见的老年综合征。虚弱对长期血管结局发生率的影响尚未明确。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在评估国家健康和老龄化趋势研究中基线时没有CHD病史的老年人,通过Fried衰弱分型衡量的虚弱与全因死亡率和MACE之间的长期关联。

研究人员通过国家健康和老龄化趋势研究,一项与医疗保险样本相关的前瞻性队列研究。既往有CHD的参与者被排除在外。在基线期,研究人员使用Fried身体虚弱分型来衡量虚弱情况。

在6年的随访期间评估了心血管结局。在4656名研究参与者中,3259名(70%)参与者在基线访问前1年没有CHD病史。与那些没有虚弱的人相比,虚弱的受试者年龄更大(平均年龄为82.1岁 vs. 75.1岁,P<0.001),更有可能是女性(68.3% vs. 54.9%,P<0.001),并且属于少数民族。身体虚弱和虚弱前状态参与者高血压、跌倒、残疾、焦虑/抑郁和多种疾病的患病率远高于身体无虚弱的参与者。在Cox时间-事件多变量模型和6年随访期间,身体虚弱患者的死亡发生率和每个个体心血管结局的发生率均显著高于非虚弱患者,包括主要不良心血管事件(MACE))[风险比(HR)为1.77,95%置信区间(CI)为1.53,2.06]、死亡(HR为2.70,95%CI为2.16,3.38)、急性心肌梗死(HR为1.95,95%CI为1.31,2.90)、卒中(HR为1.71,95%CI为1.34,2.17)、外周血管疾病(HR为1.80,95%CI为1.44,2.27)和冠状动脉疾病(HR为1.35,95%CI为1.11,1.65)。

由此可见,在非CHD患者中,身体虚弱是MACE发生发展的一个危险因素。需要努力识别非CHD患者的虚弱状态,并采取干预措施来限制或逆转虚弱状态,如果成功,可能会限制随后的不良心血管事件。

原始出处:

Abdulla A Damluji.et al.Frailty and cardiovascular outcomes in the National Health and Aging Trends Study.European Heart Journal.2021.https://doi.org/10.1093/eurheartj/ehab468

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    2021-08-02 zhaojie88
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    2021-08-02 slcumt
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    2021-07-31 ms5000000518166734

    已读已读已读一对一对,学习学习学习学习,受益匪浅

    0

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    2021-07-31 医鸣惊人

    认真学习了

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