铁死亡(Ferroptosis):一种新的细胞死亡方式

2014-01-03 关鹏,石振华,李亚青,王娜 生物化学与生物物理学进展

 Ferroptosis是近年来发现的一种由铁依赖的氧化损伤引起的细胞死亡模式,与凋亡、坏死、自噬不同。 这一死亡过程的标志为细胞质和脂质活性氧增多、线粒体变小以及线粒体膜密度较大。Ferroptosis与谷氨酸引起的兴奋性毒性类似。研究发 现,ferroptosis同细胞凋亡一样受细胞内信号通路的严密调节,这些信号通路包括铁稳态的调节通路、RAS通路以胱氨酸转运通路。对 Ferr

 Ferroptosis是近年来发现的一种由铁依赖的氧化损伤引起的细胞死亡模式,与凋亡、坏死、自噬不同。 这一死亡过程的标志为细胞质和脂质活性氧增多、线粒体变小以及线粒体膜密度较大。Ferroptosis与谷氨酸引起的兴奋性毒性类似。研究发 现,ferroptosis同细胞凋亡一样受细胞内信号通路的严密调节,这些信号通路包括铁稳态的调节通路、RAS通路以胱氨酸转运通路。对 Ferroptosis的深入研究表明,ferroptosis在神经退行性疾病的发生发展及未来定向杀死癌细胞方面具有重要作用。铁死亡:一种新的细胞死亡方式.pdf

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  1. [GetPortalCommentsPageByObjectIdResponse(id=64541, encodeId=235d64541fc, content=ferroptosis 希望有很多信息可以了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C338D7BD03B2326.jpg, createdBy=4a511688107, createdName=奋斗的小狮子, createdTime=Tue Feb 16 22:59:00 CST 2016, time=2016-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19629, encodeId=6fcb196291c, content=怎么注册了还是下载不了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42961620665, createdName=DorisYangqiuhu, createdTime=Mon Apr 06 19:43:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17334, encodeId=e5161e334b9, content=很好,第一次听说, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc241616257, createdName=Lkp123, createdTime=Sun Mar 01 23:27:00 CST 2015, time=2015-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703570, encodeId=89531e035700a, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Mon Dec 01 17:50:00 CST 2014, time=2014-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464152, encodeId=a2091464152d3, content=<a href='/topic/show?id=34e9e35563' target=_blank style='color:#2F92EE;'>#Ferroptosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7355, encryptionId=34e9e35563, topicName=Ferroptosis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d856597444, createdName=sunmin0221, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2016-02-16 奋斗的小狮子

    ferroptosis 希望有很多信息可以了解

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=64541, encodeId=235d64541fc, content=ferroptosis 希望有很多信息可以了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C338D7BD03B2326.jpg, createdBy=4a511688107, createdName=奋斗的小狮子, createdTime=Tue Feb 16 22:59:00 CST 2016, time=2016-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19629, encodeId=6fcb196291c, content=怎么注册了还是下载不了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42961620665, createdName=DorisYangqiuhu, createdTime=Mon Apr 06 19:43:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17334, encodeId=e5161e334b9, content=很好,第一次听说, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc241616257, createdName=Lkp123, createdTime=Sun Mar 01 23:27:00 CST 2015, time=2015-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703570, encodeId=89531e035700a, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Mon Dec 01 17:50:00 CST 2014, time=2014-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464152, encodeId=a2091464152d3, content=<a href='/topic/show?id=34e9e35563' target=_blank style='color:#2F92EE;'>#Ferroptosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7355, encryptionId=34e9e35563, topicName=Ferroptosis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d856597444, createdName=sunmin0221, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2015-04-06 DorisYangqiuhu

    怎么注册了还是下载不了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=64541, encodeId=235d64541fc, content=ferroptosis 希望有很多信息可以了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C338D7BD03B2326.jpg, createdBy=4a511688107, createdName=奋斗的小狮子, createdTime=Tue Feb 16 22:59:00 CST 2016, time=2016-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19629, encodeId=6fcb196291c, content=怎么注册了还是下载不了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42961620665, createdName=DorisYangqiuhu, createdTime=Mon Apr 06 19:43:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17334, encodeId=e5161e334b9, content=很好,第一次听说, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc241616257, createdName=Lkp123, createdTime=Sun Mar 01 23:27:00 CST 2015, time=2015-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703570, encodeId=89531e035700a, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Mon Dec 01 17:50:00 CST 2014, time=2014-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464152, encodeId=a2091464152d3, content=<a href='/topic/show?id=34e9e35563' target=_blank style='color:#2F92EE;'>#Ferroptosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7355, encryptionId=34e9e35563, topicName=Ferroptosis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d856597444, createdName=sunmin0221, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2015-03-01 Lkp123

    很好,第一次听说

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=64541, encodeId=235d64541fc, content=ferroptosis 希望有很多信息可以了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C338D7BD03B2326.jpg, createdBy=4a511688107, createdName=奋斗的小狮子, createdTime=Tue Feb 16 22:59:00 CST 2016, time=2016-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19629, encodeId=6fcb196291c, content=怎么注册了还是下载不了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42961620665, createdName=DorisYangqiuhu, createdTime=Mon Apr 06 19:43:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17334, encodeId=e5161e334b9, content=很好,第一次听说, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc241616257, createdName=Lkp123, createdTime=Sun Mar 01 23:27:00 CST 2015, time=2015-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703570, encodeId=89531e035700a, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Mon Dec 01 17:50:00 CST 2014, time=2014-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464152, encodeId=a2091464152d3, content=<a href='/topic/show?id=34e9e35563' target=_blank style='color:#2F92EE;'>#Ferroptosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7355, encryptionId=34e9e35563, topicName=Ferroptosis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d856597444, createdName=sunmin0221, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-12-01 surilei
  5. [GetPortalCommentsPageByObjectIdResponse(id=64541, encodeId=235d64541fc, content=ferroptosis 希望有很多信息可以了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160216/IMG56C338D7BD03B2326.jpg, createdBy=4a511688107, createdName=奋斗的小狮子, createdTime=Tue Feb 16 22:59:00 CST 2016, time=2016-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19629, encodeId=6fcb196291c, content=怎么注册了还是下载不了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42961620665, createdName=DorisYangqiuhu, createdTime=Mon Apr 06 19:43:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17334, encodeId=e5161e334b9, content=很好,第一次听说, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc241616257, createdName=Lkp123, createdTime=Sun Mar 01 23:27:00 CST 2015, time=2015-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703570, encodeId=89531e035700a, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Mon Dec 01 17:50:00 CST 2014, time=2014-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464152, encodeId=a2091464152d3, content=<a href='/topic/show?id=34e9e35563' target=_blank style='color:#2F92EE;'>#Ferroptosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7355, encryptionId=34e9e35563, topicName=Ferroptosis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d856597444, createdName=sunmin0221, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]

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